Recombinant Rat Axin-2 (Axin2), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Axin2

Uniprot NO.

O70240

Alternative Names

Axin2Axin-2; Axin-like protein; Axil; Axis inhibition protein 2; Conductin

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

1-838

Target Protein Sequence

MSSAVLVTLL PDPSSSFRED APRPPVPGEE GETPPCQPSV GKVQSTKPMP VSSNARRNED GLGEPEGRAS PDSPLTRWTK SLHSLLGDQD GAYLFRTFLE REKCVDTLDF WFACNGFRQM NLKDTKTLRV AKAIYKRYIE NNSVVSKQLK PATKTYIRDG IKKQQIGSVM FDQAQTEIQA VMEENAYQVF LTSDIYLEYV RSGGENTAYM SNGGLGSLKV LCGYLPTLNE EEEWTCADLK CKLSPTVVGL SSKTLRATAS VRSTETAENG FRSFKRSEPV NPYHVGSGYV FAPATSANDS ELSSDALTDD SMSMTDSSVD GIPPYRMGSK KQLQREMHRS VKANGQVSLP HFPRTHRLPK EMTPVEPAAF AAELISRLEK LKLELESRHS LEERLQQIRE DEEKEGSEQA LSSRDGAPVQ HPLALLPSGS YEEDPQTILD DHLSRVLKTP GCQSPGVGRY SPRSRSPDHH HHHHQQCHAL LPTGGKLPPE AACPLLGGKS FLTKQTTKHV HHHYIHHHAV PKTKEEIEAE ATQRVRCLCP GGTDYYCYSK CKSHSKPPEP LPGEQFCGSR GGTLPKRNTK GTEPGLALPA REGGMSSAAG APQLPGEEGD RSQDVWQWML ESERQSKSKP HSTQSIRKSY PLESARAPPG ERVSRHHLLG ASGHPRSAAR AHPFTQDPAM PPLTPPNTLA QLEEACRRLA EVSKPQKQRC CVASQQRDRN HPATGQAGPT SFSNPSLASE DHKEPKRLAS VHALQASELI VTYFFCGEEI PYRRMLKAQS LTLGHFKEQL SKKGNYRYYF KKASDEFACG AVFEEIWDDE TVLPMYEGRI LGKVERID
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B.

Gene References into Functions

Results suggest that Axin2 plays a key role in adipocyte and osteoblastic differentiation by controlling beta-catenin expression. PMID:23996200
Axin2 expression in the E19 gubernaculum confirms canonical Wnt pathway activation. Its absence in the core of flutamide-treated gubernacula indicates Wnt down-regulation PMID:22152883

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Subcellular Location

Cytoplasm.

Tissue Specificity

Expressed in lung and thymus.

Database Links

UNIGENE: Rn.162212

KEGG: rno:29134

STRING: 10116.ENSRNOP00000004898

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