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Recombinant Rat Atrial natriuretic peptide receptor 2 (Npr2), partial

Recombinant Rat Atrial natriuretic peptide receptor 2 (Npr2), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Npr2

Uniprot NO.

P16067

Alternative Names

Npr2Atrial natriuretic peptide receptor 2; EC 4.6.1.2; Atrial natriuretic peptide receptor type B; ANP-B; ANPR-B; NPR-B; Guanylate cyclase B; GC-B

Species

Rattus norvegicus (Rat)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Receptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon binding of its ligand. May play a role in the regulation of skeletal growth.

Gene References into Functions

Suppression of Npr1, not Npr2 gene function induces hypertrophic growth in cardiomyocytes in vitro. PMID:28743500
Dephosphorylation and inactivation of NPR2 guanylyl cyclase in granulosa cells contributes to the luteinizing hormone-induced decrease in cGMP that causes resumption of meiosis in rat oocytes. PMID:25183874
These data indicate common and distinct properties of particulate guanylyl cyclase receptors in somatotropes. PMID:24352806
Provide direct evidence for the presence and synthesis of ANP and its receptors in both neuronal and non-neuronal cells within the cochlear spiral ganglion. PMID:24333928
Six phosphorylation sites were identified in rat GC-B (S513, T516, S518, S523, S526, and T529), and all six sites were also identified in human GC-B. PMID:20977274
At postnatal day 1, the vast majority of GC-B (but not GC-A) molecules contain additionally an O-linked carbohydrate modification of about 1 kDa in mass and a further modification of similar size which is resistant to enzymatic removal. PMID:20880010
Results show that VILIP-1 regulates the cell surface localization of natriuretic peptide receptor B. PMID:20079378
Study revealed that GC-B predominates in the developing and GC-A in the adult brain, with regional differences each between cerebral cortex, cerebellum, and brain stem. PMID:19837875
investigated the localization and function of the CNP receptor NPR-B (or GC-B) in the adult rat heart ventricle; found the expression of GC-B is predominantly in nonmyocytes. PMID:12003819
hyperosmotic and lysophosphatidic acid-dependent inhibition of NPRB is mediated by calcium-dependent phosphorylation PMID:15371450
CNP is capable of autoregulating the expression of its cognate receptor, type B natriuretic peptide receptor. PMID:16109786
The data suggest that pressure overload is accompanied by upregulation of not only ANP and BNP but also their receptors NPR-A and NPR-C in the left ventricle. PMID:16272201
Deregulation of NPR-2 function in astrocytes by ammonia may contribute to neurophysiological symptoms of hyperammonemia. PMID:17629948