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Recombinant Rat Apoptotic protease-activating factor 1 (Apaf1), partial

Recombinant Rat Apoptotic protease-activating factor 1 (Apaf1), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

Apaf1

Purity

>85% (SDS-PAGE)

Target Names

Apaf1

Uniprot NO.

Q9EPV5

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

1-1249

Target Protein Sequence

MDAKARNCLL QHKEALEKDI KTSYIMDHMI SNGVLTVVEE EKVKSQATQY QRAAALIKMI LNKDNYAYIS FYNALLHEGY KDLAGLLHSG LPLVSSSSGK DTDGGNTSFV RTVLCEGGVP QRPVIFVTRK KLVSAIQQKL WKLNGEPGWV TIYGMAGCGK SVLAAEAVRD HALLEGCFSG GVHWVSIGKQ DKSGLLMKLQ NLCTRLGQEE SFSQRLPLNI EEAKDRLRVL MLRKHPRSLL ILDDVWDPWV LKAFDNQCQI LLTTRDKSVT DSVMGPKYVI PVESGLGKEK GLEILSLFVN MKKEDLPVEA HSIIKECKGS PLVVSLVGAL LRDFPNRWAY YLRQLQNKQF KRIRKSSSYD YEALDEAMSI SVEMLREDIK DYYTDLSILQ KDVKVPTKVL CVLWDLETEE VEDILQEFVN KSLLFCNRNG KSFCYYLHDL QVDFLTEKNR SQLQDLHRKM VTQFQRYHQP HTLSPGQEDC MYWYNFLAYH MASAGMHKEL CALMFSLDWI KAKTELVGPA HLIHEFVEYR HILDEKDCAV CENFQEFLSL NGHLLGRQPF PNIVQLGLCE PETSEVYQQA KLQAKQEVDT GRLYLEWINK KTIKNLSRLV VRPHTDAVYH ACFSQDGQRI ASCGADKTLQ VFKAETGEKL LDIKAHEDEV LCCAFSSDDS YIATCSVDKK VKIWDSGTGK LVHTYEEHSE QVNCCHFTNK SNHLLLATGS NDSFLKLWDL NQKECRNTMF GHTNSVTHCR FSPDDELLAS CSADGTLKLW DVRSANEKKS INVKRFFLSS EDPPEDVEVI VKCCSWSADG DRIIVAAKNK VLLLDIHTSG LLTEIHTGHH STIQYCDFSP YDHLAVIALS QYCVELWNID SRVKVADCRG HLSWVHGVMF SPDGSSFLTA SDDQTIRVWE TRKVCKNSAI VLKQEIDVVF QENEMMVLAV DNIRGLQLIA GKTGQIDYLP EAQVSCCCLS PHLEYVAFGD EEGAIKIIEL PNNRVFSSGI GHKKAVRHIQ FTADGKTLIS SSEDSVIQVW NWQTEEYVFL QAHQETVKDF RLLRDSRLLS WSFDGTVKVW NVITGRIERD FTCHQGTVLS CAISSDATKF SSTSADKTAK IWSFELPSPL HELKGHNSCV RCSAFSLDGI LLATGDDNGE IRIWNVSDGQ LLHLCAPISI EEGTATHGGW VTDVCFSPDR KMLVSAGGYL KWWNVVTGES SQTFYTNGTN LKKIHVSPDF RTYVTVDNLG ILYILQVLE
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Regulates programmed cell death; necessary for normal brain development. Participates with pro-caspase-9 (Apaf-3) in the cytochrome c-dependent activation of caspase-3, leading to apoptosis. This activation requires ATP.

Gene References into Functions

ZYZ-488 as a novel small molecule competitive inhibitor of Apaf-1, with the great potential for treating cardiac ischemia. PMID:27443636
miR-183 was induced in protective postconditioning and reduced reperfusion injury of the livers via the targeting of apoptotic signaling. miR-183 mediated the tolerance induced by iPoC in livers via Apaf-1 repressing. PMID:27580417
MicroRNA-17-mediated down-regulation of Apaf-1 attenuates apoptosome formation and subsequent apoptosis of cardiomyocytes. PMID:26265044
results provide evidence that Apaf-1 pharmacological inhibition has therapeutic potential for the treatment of apoptosis-related diseases. PMID:25330150
Alteration of apoptotic protease-activating factor-1 (APAF-1)-dependent apoptotic pathway during development of rat brain and liver. "APAF-1" PMID:11754744
erythropoietin maintains both genomic DNA integrity and cellular membrane asymmetry through parallel pathways that prevent the induction of Apaf-1 and preserve mitochondrial membrane potential in conjunction with enhanced Bcl-XL expression PMID:12621307
Results show that nPC12 transition to dPC12 cells afforded protection against oxidative challenge due to maintenance of reduced GSH/GSSG and decreased Apaf-1 expression. PMID:15877105
The subcellular distribution of the apoptosome scaffold protein apoptotic protease-activating factor 1 (Apaf-1) before and after triggering apoptosis in single somatotrophs is reported. PMID:16207793
Chronic hyperglycemia exacerbated apoptosis and exaggerated loss of cytosolic and mitochondrial redox balance, impaired G6PD activity, and enhanced expression of Apaf-1. PMID:16375719