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Recombinant Rat Amine oxidase [flavin-containing] B (Maob), partial

Recombinant Rat Amine oxidase [flavin-containing] B (Maob), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Maob

Uniprot NO.

P19643

Alternative Names

Maob; Amine oxidase [flavin-containing] B; Monoamine oxidase type B; MAO-B

Species

Rattus norvegicus (Rat)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine.

Gene References into Functions

Benzylamine and serotonin oxidation were catalyzed by MAO-B and MAO-A, respectively, to aldehydes. These were derivatized with DNPH, and the corresponding quinones were further formed by adding NaOH. These DNPH derivatives with large conjugated structures were directly measured spectrophotometrically at 465 nm and 425 nm PMID:27503749
Monoamine oxidase B is increased in prefrontal cortex following ethanol administration. PMID:20204567
investigation of topological orientation of MAO-B (and MAO-A) in liver mitochondrial membranes PMID:21341713
Dopamine induces Ca2+ signaling in astrocytes through reactive oxygen species generated by monoamine oxidase PMID:20547771
significant effects of hormone replacement and gonadectomy on catechol-O-methyltransferase and monoamine oxidase isoforms in both striatum and cortex PMID:19909795
in serotonergic neurons only mitochondria lacking monoamine oxidase type B are transported by axonal flow up to axon terminals. PMID:12379239
MAO-B is localized to the outer membranes of mitochondria in nerve terminals of afferent and efferent fibers, as well as in taste bud cells. PMID:14697889
MAOB is involved in the inactivation mechanism of histamine that is released from ECL cells and activates parietal cells to secrete gastric acid. PMID:14986002
monoamine oxidase activity has a role in regulating reactive oxygen species production and aluminum-induced mitochondrial permeability transition PMID:15526171
Presence of monoamine oxidase type B protein but absence of associated enzyme activity in neurons within the inferior olive nucleus of the rat. PMID:16098487
These data suggest that the structural properties of the active site cavities in rat MAOs are significantly different from the two human enzymes, which correlates with the differences in the inhibitor specificities between human and rat MAOs. PMID:18092818
localization of monoamine oxidase type B in liver; no MAOB was found in endothelial cells, hepatic stellate cells, or Kupffer cells; MAOB was localized to the mitochondrial outer membrane of hepatocytes PMID:18502718
These results suggest that LPS induces chronic wounds via elevated MAO/B-mediated increases in H(2)O(2) and TNF-alpha activity by epithelial cells and is further associated with more distant effects on systemic oxidative stress and alveolar bone loss. PMID:19779138