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Recombinant Rat Aggrecan core protein (Acan), partial

Recombinant Rat Aggrecan core protein (Acan), partial

Baculovirus
Mammalian cell

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Acan

Uniprot NO.

P07897

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

20-2124

Target Protein Sequence

E EVPDHDNSLS VSIPQPSPLK ALLGTSLTIP CYFIDPMHPV TTAPSTAPLT PRIKWSRVSK EKEVVLLVAT EGQVRVNSIY QDKVSLPNYP AIPSDATLEI QNLRSNDSGI YRCEVMHGIE DSEATLEVIV KGIVFHYRAI STRYTLDFDR AQRACLQNSA IIATPEQLQA AYEDGFHQCD AGWLADQTVR YPIHTPREGC YGDKDEFPGV RTYGIRDTNE TYDVYCFAEE MEGEVFYATS PEKFTFQEAA NECRTVGARL ATTGQLYLAW QGGMDMCSAG WLADRSVRYP ISKARPNCGG NLLGVRTVYL HANQTGYPDP SSRYDAICYT GEDFVDIPEN FFGVGGEEDI TIQTVTWPDL ELPLPRNITE GEARGNVILT AKPIFDMSPT VSEPGEALTL APEVGTTVFP EAGERTEKTT RPWGFPEEAT RGPDSATAFA SEDLVVRVTI SPGAVEVPGQ PRLPGGVVFH YRPGSTRYSL TFEEAQQACI RTGAAIASPE QLQAAYEAGY EQCDAGWLQD QTVRYPIVSP RTPCVGDKDS SPGVRTYGVR PSSETYDVYC YVDKLEGEVF FATQMEQFTF QEAQAFCAAQ NATLASTGQL YAAWSQGLDK CYAGWLADGT LRYPIVNPRP ACGGDKPGVR TVYLYPNQTG LPDPLSKHHA FCFRGVSVVP SPGGTPTSPS DIEDWIVTRV EPGVDAVPLE PETTEVPYFT TEPEKQTEWE PAYTPVGTSP LPGIPPTWLP TVPAAEEHTE SPSASQEPSA SQVPSTSEEP YTPSLAVPSG TELPSSGDTS GAPDLSGDFT GSTDTSGRLD SSGEPSGGSE SGLPSGDLDS SGLGPTVSSG LPVESGSASG DGEIPWSSTP TVDRLPSGGE SLEGSASASG TGDLSGLPSG GEITETSASG TEEISGLPSG GDDLETSTSG IDGASVLPTG RGGLETSASG VEDLSGLPSG EEGSETSTSG IEDISVLPTG ESPETSASGV GDLSGLPSGG ESLETSASGV EDVTQLPTER GGLETSASGI EDITVLPTGR ENLETSASGV EDVSGLPSGK EGLETSASGI EDISVFPTEA EGLETSASGG YVSGIPSGED GTETSTSGVE GVSGLPSGGE GLETSASGVE DLGLPTRDSL ETSASGVDVT GYPSGREDTE TSVPGVGDDL SGLPSGQEGL ETSASGAEDL GGLPSGKEDL VGSASGALDF GKLPSGTLGS GQTPEASGLP SGFSGEYSGV DIGSGPSSGL PDFSGLPSGF PTVSLVDSTL VEVITATTAS ELEGRGTISV SGSGEESGPP LSELDSSADI SGLPSGTELS GQTSGSLDVS GETSGFFDVS GQPFGSSGTG EGTSGIPEVS GQAVRSPDTT EISELSGLSS GQPDVSGEGS GILFGSGQSS GITSVSGETS GISDLSGQPS GFPVLSGTTP GTPDLASGAM SGSGDSSGIT FVDTSLIEVT PTTFREEEGL GSVELSGLPS GETDLSGTSG MVDVSGQSSG AIDSSGLISP TPEFSGLPSG VAEVSGEVSG VETGSSLSSG AFDGSGLVSG FPTVSLVDRT LVESITLAPT AQEAGEGPSS ILEFSGAHSG TPDISGDLSG SLDQSTWQPG WTEASTEPPS SPYFSGDFSS TTDASGESIT APTGSGETSG LPEVTLITSE LVEGVTEPTV SQELGHGPSM TYTPRLFEAS GEASASGDLG GPVTIFPGSG VEASVPEGSS DPSAYPEAGV GVSAAPEASS QLSEFPDLHG ITSASRETDL EMTTPGTEVS SNPWTFQEGT REGSAAPEVS GESSTTSDID AGTSGVPFAT PMTSGDRTEI SGEWSDHTSE VNVTVSTTVP ESRWAQSTQH PTETLQEIGS PNPSYSGEET QTAETAKSLT DTPTLASPEG SGETESTAAD QEQCEEGWTK FQGHCYRHFP DRETWVDAER RCREQQSHLS SIVTPEEQEF VNKNAQDYQW IGLNDRTIEG DFRWSDGHSL QFEKWRPNQP DNFFATGEDC VVMIWHERGE WNDVPCNYQL PFTCKKGTVA CGEPPAVEHA RTLGQKKDRY EISSLVRYQC TEGFVQRHVP TIRCQPSADW EEPRITCTDP NTYKHRLQKR TMRPTRRSRP SMAH
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.

Gene References into Functions

To elucidate the transcriptional mechanism that leads to abundant expression of aggrecan by chondrocytes, it screened for enhancer elements in 130 kb of the aggrecan gene, Agc1, using a reporter assay system that we previously developed. PMID:24554731
Local adipose tissue stem cells protected the bronchial stump after pneumonectomy and induced local changes in Agc1 gene expression. PMID:24647564
Data suggest that expression of aggrecan and matrix metallopeptidase 13 in femur of female neonatal rats is altered by maternal vitamin A status and neonatal diet (i.e., supplementation with vitamin A and retinoic acid). PMID:22357747
We suggest that the role of aggrecan is to maintain retinal ganglion cell dendritic structure in the inner plexiform layer and to provide adequate support and flexibility for the photoreceptor outer segments, which is necessary to maintain their function. PMID:22306080
Data show that an increase in collagen-II, aggrecan, and Sox-9 protein expression in NP and AF regions of the disc was detected in the exercised rats. PMID:20592578
Using in vitro assays of cell migration, we show that aggrecan produced by astrocytes is involved in the inhibition of Schwann cell motility on astrocytic monolayers. PMID:20155822
A remote upstream element regulates tissue-specific expression of the rat aggrecan gene PMID:11834732
cleaved by ADAMTS1 and diffrenteially inhibited by metalloproteinase inhibitors PMID:12054629
Data suggest that versican and aggrecan have partially complementary roles during central nervous system development. PMID:12701107
PI3K/AKT signaling controls aggrecan gene expression, in part by modulating Sox9 expression and activity in cells of the nucleus pulposus. PMID:19711351