Home
Product
Protein
Recombinant Proteins
Recombinant Rat Activity-dependent neuroprotector homeobox protein (Adnp), partial

Recombinant Rat Activity-dependent neuroprotector homeobox protein (Adnp), partial

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
Have Questions?	Leave a Message or Start an on-line Chat

Product Details
Related Products
Customer Reviews and Q&A
Target Background

Product Details

Abbreviation

Adnp

Purity

>85% (SDS-PAGE)

Target Names

Adnp

Uniprot NO.

Q9JKL8

Alternative Names

Adnp; Activity-dependent neuroprotector homeobox protein; Activity-dependent neuroprotective protein

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

1-823

Target Protein Sequence

MGLPPRISSL ASGNVRSLPS QQMVNRLSIP KPNLNSTGVN MMSNVHLQQN NYGVKSVGQS YGVGQSVRLG LGGNAPVSIP QQSQSVKQLL PSGNGRSYGL GAEQRPPAAA RYSLQTANTS SLPPGQVKSP SVSQSQASRV LGQSSSKPPP AATGPPPSNH CATQKWKICT ICNELFPENV YSVHFEKEHK AEKVPAVANY IMKIHNFTSK CLYCNRYLAT DTLLNHMLIH GLSCPYCRST FNDVEKMAAH MRMVHIDEEM GPKTDSTLSF DLTLQQGSHT NIHLLVTTYN LRDAPAESVA YHAQNNAPVP PKPQPKVQEK ADVPVKSSPQ AAVPYKKDVG KTLCPLCFSI LKGPISDALA HHLRERHQVI QTVHPVEKKL TYKCIHCLGV YTSNMTASTI TLHLVHCRGV GKTQNGQDKT NAPSRLNQSP GLAPVKRTYE QMEFPLLKKR KLEDENDSPG CFEEKPEEPV VLALDPKGHE DDSYEARKSF LTKYFNKQPY PTRREIEKLA ASLWLWKSDI ASHFSNKRKK CVRDCEKYKP GVLLGFNMKE LNKVKHEMDF DAEWLFENHD EKASRVNASK TVDKKHNLGK EDDSFSDSFE HLEEESNGSG GPFDPVFEVE PKIPSDNAEE PVPKVIPEGA LESEKLDQKE EEDGSKYETI HLTEERAKLM HDASDSEVDQ DDVVEWKDGA SPSESGPGSR QVSDFEDNTC EMKPGTWSDE SSQSEDARSS KPAAKKKATV QDDTEQLKWK NSSYGKVEGF WSKDQSQWEN ASENAERLPN PQIEWQNSTI DSEDGEQFDS MTDGVADPMH GSLTGVKLSS QQA
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

■ Customer Reviews

Submit a Review here

Target Background

Function(From Uniprot)

Potential transcription factor. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation.

Gene References into Functions

These findings demonstrate that the down-regulation of protein ADNP is an early pathological alteration and may contribute to dopaminergic neurodegeneration in Parkinson's disease PMID:27003787
the newly identified shared microtubule target of NAP/ADNP is directly implicated in synaptic plasticity, explaining the breadth and efficiency of neuroprotective/neurotrophic capacities PMID:25178163
NAP is an ADNP derived peptide that modulates the tubulin pool in mice and rats PMID:23272107
An endogenous PACAP-mediated ADNP signaling system increases malignant peripheral nerve sheath tumor cell resistance to hydrogen-peroxide-induced death upon serum starvation. PMID:22454142
Results suggest that nitric oxide regulates activity-dependent neuroprotective protein in the dentate gyrus under both basal and pathophysiological conditions. PMID:19130308
NAPVSIPQ peptide component was shown to inhibit Abeta aggregation; part of the neuroprotective mechanism is through modulation of toxic protein folding in the extracellular milieu PMID:14706557
These observations suggest a complex interaction of NO-NGF with PPTA/SP and ADNP-VIP in neuron-glial communication when neurons are stressed. PMID:17952636
Widespread expression of ADNP may correlate with wide-ranging protective effects, and the cytoplasmic and axonal localisation of ADNP-like immunoreactivity suggests additional, non-transcriptional functions of ADNP. PMID:18072088
These findings identify a mechanism for ADNP regulation of glial-neuronal interactions in developing cerebellum and a pathogenesis of ethanol neurotoxicity. PMID:19047645