Recombinant Rat 14-3-3 protein beta/alpha (Ywhab)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Ywhab

Uniprot NO.

P35213

Alternative Names

Ywhab14-3-3 protein beta/alpha; Prepronerve growth factor RNH-1; Protein kinase C inhibitor protein 1; KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha; N-terminally processed]

Species

Rattus norvegicus (Rat)

Source

Yeast

Expression Region

1-246

Target Protein Sequence

MTMDKSELVQ KAKLAEQAER YDDMAAAMKA VTEQGHELSN EERNLLSVAY KNVVGARRSS WRVISSIEQK TERNEKKQQM GKEYREKIEA ELQDICSDVL ELLDKYLILN ATHAESKVFY LKMKGDYFRY LSEVASGDNK QTTVSNSQQA YQEAFEISKK EMQPTHPIRL GLALNFSVFY YEILNSPEKA CSLAKTAFDE AIAELDTLNE ESYKDSTLIM QLLRDNLTLW TSENQGDEGD AGEGEN
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13.

Gene References into Functions

The expression of YWHAB was upregulated by oleic acid in a concentrationdependent manner in vascular smooth muscle cells. PMID:29749466
The results indicate that hyperglycemia-induced up-regulation of YWHAB in endothelial cell plays a significant role in intimal hyperplasia following carotid artery injury by enhancing endothelial cell proliferation and migration. PMID:28684312
This study reveals that 14-3-3 gamma protein is present in oligodendroglial cells and that 14-3-3 gamma deficiency leads to more severe chronic EAE with enhanced demyelination. PMID:26438180
Results showed that sepsis alters the expression of 14-3-3 beta isoform in a time-, cell-, and topography-dependent manner, with the choroid plexus showed constantly increased beta isoform expression. PMID:21618583
Results indicate that the phosphorylation-dependent interaction between 14-3-3beta and alphaII spectrin acts as a switch between positive and negative regulation of neurite outgrowth stimulated by NCAM. PMID:20598904
14-3-3beta is a p90 ribosomal S6 kinase (RSK) isoform 1-binding protein that negatively regulates RSK kinase activity PMID:12618428
mechanism of CaM kinase IIdeltaC silencing of MEF-2-dependent genes is by phosphorylation of 14-3-3beta, which allows HDAC to return to the nucleus to reform a complex with MEF2, thereby silencing MADS box-dependent gene induction in smooth muscle PMID:12619878
Kainic acid evoked seizures triggered Bid protein cleavage and a commensurate increase in binding of Bid to 14-3-3 within injured hippocampus suggesting 14-3-3 proteins may target active and inactive conformations of pro-apoptotic Bcl-2 death agonists PMID:12871587
individual subdomains in the GSM (MCR I through V) play diverse but crucial roles in cooperation with essential trans-acting cofactors such as 14-3-3 proteins to mediate the glucose response of ChREBP PMID:18436566
Data suggest the presence of 14-3-3zeta within CSF may be a biomarker of acute seizure damage. PMID:18484353