Recombinant Rabbit Stromelysin-1 (MMP3)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

MMP3

Uniprot NO.

P28863

Species

Oryctolagus cuniculus (Rabbit)

Source

Yeast

Expression Region

101-478

Target Protein Sequence

FSTFPGTPKW TKTHLTYRIV NYTPDLPRDA VDAAIEKALK VWEEVTPLTF SRKYEGEADI MISFGVREHG DFIPFDGPGN VLAHAYAPGP GINGDAHFDD DEQWTKDTTG TNLFLVAAHE LGHSLGLFHS ANPEALMYPV YNAFTDLARF RLSQDDVDGI QSLYGPAPAS PDNSGVPMEP VPPGSGTPVM CDPDLSFDAI STLRGEILFF KDRYFWRKSL RILEPEFHLI SSFWPSLPSA VDAAYEVISR DTVFIFKGTQ FWAIRGNEVQ AGYPRSIHTL GFPSTIRKID AAISDKERKK TYFFVEDKYW RFDEKRQSLE PGFPRHIAED FPGINPKIDA VFEAFGFFYF FSGSSQSEFD PNAKKVTHVL KSNSWFQC
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase.

Gene References into Functions

Compromised autophagy may be related to the osteoarthritis progression; JNK and p38 MAPKs up-regulate MMP3 and down-regulate autophagy. PMID:26873249
the total content and active forms of matrix metalloproteinases (MMPs)-1, -3, and -13 was measured to assess the potential role of the mechanical environment in regulation of matrix turnover by ligament fibroblasts. PMID:23879595
chitosan-pDNA nanoparticles encoding shRNA targeting MMP-3 and -13 had great potential in silencing the dedifferentiation-related genes for regenerating prolonged and endurable cartilage. PMID:23520014
Ulinastatin effectively inhibited the increased expression of MMP-2, MMP-3, and iNOS in degenerated NP cells induced by IL-1beta in vitro. PMID:22853554
Exposure to long periods of light irrespective of its characteristics leads to the increased expression of some matrix metalloprpteases. PMID:20238014
Tongxinluo can inhibit the expression of MMP-3 and 9 and increase the expression of PPARgamma in atherosclerotic rabbits. PMID:19778818