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Recombinant Rabbit Progesterone receptor (PGR), partial

Recombinant Rabbit Progesterone receptor (PGR), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

PGR

Uniprot NO.

P06186

Species

Oryctolagus cuniculus (Rabbit)

Source

Yeast

Expression Region

1-930

Target Protein Sequence

MTELKAKEPR APHVAGGAPS PTEVGSQLLG RPDPGPFQGS QTSEASSVVS AIPISLDGLL FPRPCQGQNP PDGKTQDPPS LSDVEGAFPG VEAPEGAGDS SSRPPEKDSG LLDSVLDTLL APSGPGQSHA SPATCEAISP WCLFGPDLPE DPRAAPATKG VLAPLMSRPE DKAGDSSGTA AAHKVLPRGL SPSRQLLLPS SGSPHWPAVK PSPQPAAVQV DEEDSSESEG TVGPLLKGQP RALGGTAAGG GAAPVASGAA AGGVALVPKE DSRFSAPRVS LAEQDAPVAP GRSPLATSVV DFIHVPILPL NHAFLATRTR QLLEGESYDG GAAAASPFVP QRGSPSASST PVAGGDFPDC TYPPDAEPKD DAFPLYGDFQ PPALKIKEEE EAAEAAARSP RTYLVAGANP AAFPDFQLAA PPPPSLPPRV PSSRPGEAAV AASPGSASVS SSSSSGSTLE CILYKAEGAP PQQGPFAPLP CKPPGAGACL LPRDGLPSTS ASGAAAGAAP ALYPTLGLNG LPQLGYQAAV LKEGLPQVYT PYLNYLRPDS EASQSPQYSF ESLPQKICLI CGDEASGCHY GVLTCGSCKV FFKRAMEGQH NYLCAGRNDC IVDKIRRKNC PACRLRKCCQ AGMVLGGRKF KKFNKVRVMR ALDAVALPQP VGIPNESQRI TFSPSQEIQL IPPLINLLMS IEPDVIYAGH DNTKPDTSSS LLTSLNQLGE RQLLSVVKWS KSLPGFRNLH IDDQITLIQY SWMSLMVFGL GWRSYKHVSG QMLYFAPDLI LNEQRMKESS FYSLCLTMWQ IPQEFVKLQV SQEEFLCMKV LLLLNTIPLE GLRSQSQFEE MRSSYIRELI KAIGLRQKGV VSSSQRFYQL TKLLDNLHDL VKQLHLYCLN TFIQSRALSV EFPEMMSEVI AAQLPKILAG MVKPLLFHKK
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation.

Gene References into Functions

PR activation around the time of mating and a post-mating decline in ovarian estradiol secretion and/or estradiol responsiveness act in parallel to terminate estrus in this species. PMID:20688069
Differential time course and tissue specific immunoreactivity for PR in the uterus of the rabbit in two progestational conditions. PMID:20434280
expression differences among PGR genotypes in oviduct and uterus and when differences appear during gestation PMID:19897621
The wide distribution of PR mRNA in the rabbit brain suggests that progesterone through PR activation is involved in several functions apart from reproductive behavior in rabbits, and that PR expression is up-regulated by estradiol in the rabbit brain. PMID:17459697