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Recombinant Rabbit Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (HCN4), partial

Recombinant Rabbit Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (HCN4), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

HCN4

Purity

>85% (SDS-PAGE)

Target Names

HCN4

Uniprot NO.

Q9TV66

Species

Oryctolagus cuniculus (Rabbit)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Hyperpolarization-activated ion channel with very slow activation and inactivation exhibiting weak selectivity for potassium over sodium ions. May contribute to the native pacemaker currents in heart (If) that regulate the rhythm of heart beat. May contribute to the native pacemaker currents in neurons (Ih). May mediate responses to sour stimuli.

Gene References into Functions

HCN4-overexpressing mouse embryonic stem cell -derived cardiomyocytes produce rapid ectopic ventricular rhythms as a biological pacemaker. PMID:29628472
Ischemia-reperfusion is harmful to the sinoatrial node and reduces the expression of HCN4. PMID:19662993
SAP97 contributes to isoform specific organization of HCN channels within specific domains in the sinoatrial node of the rabbit. PMID:19336273
HCN protein expression in the rabbit pacemaker region, was investigated. PMID:19394343

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Subcellular Location

Cell membrane; Multi-pass membrane protein.

Protein Families

Potassium channel HCN family

Tissue Specificity

Highly expressed in the heart sinoatrial node (SAN). Not detected in atrium, ventricle, forebrain or cerebellum. Detected at very low levels in total brain.

Database Links

UNIGENE: Ocu.2366

KEGG: ocu:100009452

STRING: 9986.ENSOCUP00000006294

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