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Recombinant Rabbit Oxidized low-density lipoprotein receptor 1 (OLR1), partial

Recombinant Rabbit Oxidized low-density lipoprotein receptor 1 (OLR1), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

OLR1

Purity

>85% (SDS-PAGE)

Target Names

OLR1

Uniprot NO.

Q9XTA8

Species

Oryctolagus cuniculus (Rabbit)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria.

Gene References into Functions

ox-LDL and LOX-1 increase due to subarachnoid hemorrhage and they may play a role in the pathogenesis of vasospasm. PMID:24949677
LOX and LOXL2 play an important role in wound healing after glaucoma filtration surgery. Targeting LOXL2 with an inhibitory monoclonal antibody (GS-607601) had a broader efficacy than targeting LOX, reducing angiogenesis and inflammation, and fibrosis. PMID:23821193
Angiotensin (1-7) inhibited LOX-1 expression and diminished Ang II-mediated inflammation in endothelial cells PMID:23233095
Elevated LOX-1 expression and inflammatory responses are induced in hypercholesterolemic rabbits by Chlamydia pneumoniae GroEL1 heat shock protein. PMID:21383245
Early treatment with fluvastatin had a crucial endothelial protective effect by down-regulating LOX-1 expression level in atherosclerotic arteries in early atherosclerosis. PMID:16255856
LOX-1 expression appears to be closely associated with tissue factor expression, apoptotic events and morphological vulnerability in atherosclerotic lesions PMID:18670075