Recombinant Rabbit Ezrin (EZR), partial

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Target Background

Product Details

Abbreviation

EZR

Purity

>85% (SDS-PAGE)

Target Names

EZR

Uniprot NO.

Q8HZQ5

Species

Oryctolagus cuniculus (Rabbit)

Source

Yeast

Expression Region

2-586

Target Protein Sequence

PKPINVRVT TMDAELEFAV QPNTTGKQLF DQVVKTIGLR EVWYFGLQYV DNKGFPTWLK LDKKVSAQEV RKENPVQFKF RAKFYPEDVS EELIQDITQK LFFLQVKEGI LSDEIYCPPE TAVLLGSYAV QAKFGDYSKE AHKAGYLSSE RLIPQRVMDQ HKLSRDQWED RIQVWHAEHR GMLKDSAMLE YLKIAQDLEM YGINYFEIKN KKGTDLWLGV DALGLNIYEK NDKLTPKIGF PWSEIRNISF NDKKFVIKPI DKKAPDFVFY APRLRINKRI LQLCMGNHEL YMRRRKPDTI EVQQMKAQAR EEKHQKQLER QQLESEKKRR EAVEQEKEQM LREKEELMMR LQDYEQKTKK AEKELSDQIQ RALQLEDERK RAQEESERLE ADRVAALRAK EELERQAADQ IKSQEQLAAE LAEYTAKIAL LEEARRRKES EVEEWQHRAR EAQDDLVKTK EELHLVMTAP PPPPPPMYEP VSYHVQEHLH EEGAESLGYS AELSSEGILD DRHEEKRITE AEKNERVQRQ LLTLSNELSQ ARDENKRTHN DIIHNENLRQ GRDKYKTLRQ IRQGNTKQRI DEFEAM
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis.

Gene References into Functions

Data suggest that Mst4 phosphorylation of Thr545 of Acap4/Asap3 in parietal cells leads to Acap4/Asap3 binding to Ser66-phosphorylated ezrin (a cytoskeletal protein); phosphorylation of Thr545 of Acap4/Asap3 is required for relocation of H,K-ATPase to apical plasma membrane and acid secretion by parietal cells. (Mst4 = serine/threonine-protein kinase Mst4; Acap4/Asap3 = GTPase-activating protein Acap4/Asap3) PMID:28808054
Spatial control of proton pump H,K-ATPase docking at the apical membrane by phosphorylation-coupled ezrin-syntaxin 3 interaction. PMID:25301939
1) NHE3 basal activity is regulated by a signaling complex that is controlled by sequential effects of two kinases, Akt and GSK-3, which act on a Ser cluster in the same NHE3 C-terminal domain that binds ezrin PMID:24398676
Ezrin-mediated F-actin interaction with the epithelial cell may direct membrane recruitment and cytoskeletal surface extension. PMID:20505040
relatively high turnover of ezrin T567 phosphorylation was observed in all three epithelia (gastric, kidney and intestine). PMID:18480298

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Subcellular Location

Apical cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection. Cell projection, microvillus membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cell projection, microvillus.

Database Links

UNIGENE: Ocu.2672

KEGG: ocu:100008846

STRING: 9986.ENSOCUP00000003322

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