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Recombinant Rabbit Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A)

Recombinant Rabbit Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

DYRK1A

Uniprot NO.

P85051

Species

Oryctolagus cuniculus (Rabbit)

Source

Yeast

Expression Region

1-200

Target Protein Sequence

QPSISDQQVS ALPYSDQIQQ PLTNQVMPDI VMLQRRWMDR YEIDSLIGKV EQEWVAIKAF LNQAQIEVRH DTEMKYYIVH LKIVDFGSSC QLGQRIVEVL GIPPAHILDQ APKFFEKLPD GTWSLKKLHN ILGVETGGPG GRFKDLILRM LDYDPKIQPY YALQHSFFKQ ETGIAGHPTY QFSANTGPAH YMTEGHLAMR
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

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Target Background

Function(From Uniprot)

Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6. Exhibits a substrate preference for proline at position P+1 and arginine at position P-3. Has pro-survival function and negatively regulates the apoptotic process. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1. This in turn inhibits TP53 activity and apoptosis.

Subcellular Location

Nucleus.

Protein Families

Protein kinase superfamily, CMGC Ser/Thr protein kinase family, MNB/DYRK subfamily

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