Recombinant Protein E6 (E6)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Uniprot NO.

P06930

Species

Human papillomavirus type 5

Source

Yeast

Expression Region

1-157

Target Protein Sequence

MAEGAEHQQK LTEKDKAELP LSIRDLAEAL GIPVIDCLIP CNFCGNFLNY LEACEFDYKR LSLIWKDYCV FACCRVCCGA TATYEFNQFY EQTVLGRDIE LASGLSIFDI DIRCQTCLAF LDIIEKLDCC GRGLPFHKVR NAWKGICRQC KHFYHDW
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Plays a major role in the induction and maintenance of cellular transformation. E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase and modulates its activity. Protects host keratinocytes from apoptosis by mediating the degradation of host BAK1. May also inhibit host immune response.

Gene References into Functions

Data show that E3 ubiquitin-protein ligase HERC1 interacts with bcl-2 homologous antagonist-killer protein BAK in HPV5 E6-expressing cells that have been damaged by UV. PMID:25408501
Beta human papillomavirus E6 expression inhibits stabilization of p53 and increases tolerance of genomic instability. PMID:24648447
The C-terminal sequence of papillomavirus 5 E6 proteins alters localization and signalling of beta1-integrin to promote cell migration. PMID:24154967
Authors show that human papillomavirus type 5 and 8 E6 are capable of reducing the steady state levels of another p53 modifying enzyme, ATM, and as a result restrict LINE-1 retrotransposition. PMID:23706308
data demonstrate that beta-HPV E6 expression can enhance the carcinogenic potential of UVB exposure by promoting p300 degradation, resulting in a reduction in ATR levels, which leads to increased thymine dimer persistence and increased UVB induced double strand breaks PMID:22807682
Beta-HPV 5 and 8 E6 degrade p300 in a proteasomal-dependent, E6AP-independent manner. E6 competes with AKT for binding to p300. PMID:21901101
Human papillomavirus type 5 E6 oncoprotein represses the transforming growth factor beta signaling pathway by binding to SMAD3. PMID:17020941