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Recombinant Pongo abelii Sphingosine-1-phosphate lyase 1 (SGPL1), partial

Recombinant Pongo abelii Sphingosine-1-phosphate lyase 1 (SGPL1), partial

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details

Abbreviation

SGPL1

Purity

>85% (SDS-PAGE)

Target Names

SGPL1

Uniprot NO.

Q5R4G0

Alternative Names

SGPL1; Sphingosine-1-phosphate lyase 1; S1PL; SP-lyase 1; SPL; SPL 1; EC 4.1.2.27; Sphingosine-1-phosphate aldolase

Species

Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis. Required for global lipid homeostasis in liver and cholesterol homeostasis in fibroblasts. Involved in the regulation of pro-inflammatory response and neutrophil trafficking. Modulates neuronal autophagy via phosphoethanolamine production which regulates accumulation of aggregate-prone proteins such as APP. Seems to play a role in establishing neuronal contact sites and axonal maintenance.

Subcellular Location

Endoplasmic reticulum membrane; Single-pass type III membrane protein; Cytoplasmic side.

Protein Families

Group II decarboxylase family, Sphingosine-1-phosphate lyase subfamily

Database Links

UNIGENE: Pab.1677

KEGG: pon:100173995

STRING: 9601.ENSPPYP00000002746

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