Recombinant Pig Vinculin (VCL), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

VCL

Uniprot NO.

P26234

Alternative Names

VCL; Vinculin; Metavinculin

Species

Sus scrofa (Pig)

Source

Yeast

Expression Region

2-1135

Target Protein Sequence

PVFHTRTIE SILEPVAQQI SHLVIMHEEG EVDGKAIPDL TAPVAAVQAA VSNLVRVGKE TVQTTEDQIL KRDMPPAFIK VENACTKLVQ AAQMLQSDPY SVPARDYLID GSRGILSGTS DLLLTFDEAE VRKIIRVCKG ILEYLTVAEV VETMEDLVTY TKNLGPGMTK MAKMIDERQQ ELTHQEHRVM LVNSMNTVKE LLPVLISAMK IFVTTKNSKN QGIEEALKNR NFTVEKMSAE INEIIRVLQL TSWDEDAWAS KKDTEAMKRA LASIDSKLNQ AKGWLRDPTA SPGDAGEQAI RQILDEAGKV GELCAGKERR EILGTCKMLG QMTDQVADLR ARGQGASPVA MQKAQQVSQG LDVLTAKVEN AARKLEAMTN SKQSIAKKID AAQNWLADPN GGPEGEEQIR GALAEARKIA ELCDDPKERD DILRSLGEIS ALTSKLADLR RQGKGDSPEA RALAKQVATA LQNLQTKTNR AVANSRPAKA AVHLEGKIEQ AQRWIDNPTV DDRGVGQAAI RGLVAEGHRL ANVMMGPYRQ DLLAKCDRVD QLTAQLADLA ARGEGESPQA RALASQLQDS LKDLKARMQE AMTQEVSDVF SDTTTPIKLL AVAATAPPDA PNREEVFDER AANFENHSGR LGATAEKAAA VGTANKSTVE GIQASVKTAR ELTPQVVSAA RILLRNPGNQ AAYEHFETMK NQWIDNVEKM TGLVDEAIDT KSLLDASEEA IKKDLDKCKV AMANIQPQML VAGATSIARR ANRILLVAKR EVENSEDPKF REAVKAASDE LSKTISPMVM DAKAVAGNIS DPGLQKSFLD SGYRILGAVA KVREAFQPQE PDFPPPPPDL EQLRLTDELA PPKPPLPEGE VPPPRPPPPE EKDEEFPEQK AGEVINQPMM MAARQLHDEA RKWSSKPGNP AAKVGIGVVA EADAADAVGF PVPSDMEDDY EPELLLMPSS QPVNQPILAA AQSLHREATK WSSKGNDIIA AAKRMALLMA EMSRLVRGGS GTKRALIQCA KDIAKASDEV TRLAKEVAKQ CTDKRIRTNL LQVCERIPTI STQLKILSTV KATMLGRTNI SDEESEQATE MLVHNAQNLM QSVKETVREA EAASIKIRTD AGFTLRWVRK TPWYQ
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.

Gene References into Functions

Results suggest that myosin VI and vinculin form a molecular apparatus that generates cohesive cell-cell contacts in cultured mammalian epithelia. PMID:17664339

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Subcellular Location

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, adherens junction. Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side.

Protein Families

Vinculin/alpha-catenin family

Database Links

UNIGENE: Ssc.11071

KEGG: ssc:396974

STRING: 9823.ENSSSCP00000010997

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