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Recombinant Pig Tissue-type plasminogen activator (PLAT), partial

Recombinant Pig Tissue-type plasminogen activator (PLAT), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

PLAT

Purity

>85% (SDS-PAGE)

Target Names

PLAT

Uniprot NO.

Q8SQ23

Alternative Names

PLAT; Tissue-type plasminogen activator; t-PA; t-plasminogen activator; tPA; EC 3.4.21.68) [Cleaved into: Tissue-type plasminogen activator chain A; Tissue-type plasminogen activator chain B]

Species

Sus scrofa (Pig)

Source

Yeast

Expression Region

36-562

Target Protein Sequence

SYRVT CRDEKTQMIY QQHQSWLRPL LRGNRVEHCW CNDGQTQCHS VPVKSCSEPR CFNGGTCLQA IYFSDFVCQC PVGFIGRQCE IDARATCYED QGITYRGTWS TTESGAECVN WNTSGLASMP YNGRRPDAVK LGLGNHNYCR NPDKDSKPWC YIFKAEKYSP DFCSTPACTK EKEECYTGKG LDYRGTRSLT MSGAFCLPWN SLVLMGKIYT AWNSNAQTLG LGKHNYCRNP DGDTQPWCHV LKDHKLTWEY CDLPQCVTCG LRQYKEPQFR IKGGLYADIT SHPWQAAIFV KNRRSPGERF LCGGILISSC WVLSAAHCFQ ERFPPHHVRV VLGRTYRLVP GEEEQAFEVE KYIVHKEFDD DTYDNDIALL QLKSDSLTCA QESDAVRTVC LPEANLQLPD WTECELSGYG KHEASSPFYS ERLKEAHVRL YPSSRCTSKH LFNKTITNNM LCAGDTRSGG DNANLHDACQ GDSGGPLVCM KGNHMTLVGV ISWGLGCGQK DVPGVYTKVT NYLNWIRDNT RP
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. During oocyte activation, plays a role in cortical granule reaction in the zona reaction, which contributes to the block to polyspermy.

Gene References into Functions

The plasminogen/plasminogen activator/plasmin system is activated during gamete interaction and regulates the sperm entry into the oocyte. PMID:22177313
Mild experimental hypothermia markedly reduces ischemia-related coronary tissue plasminogen activator release, which may contribute to the cardioprotective effect of hypothermia. PMID:19499190
a fast beta2 agonist-mediated local release of t-PA into the coronary vasculature was demonstrated. For total t-PA, this response was characterised by a biphasic release profile PMID:14597973
ADP acting on the endothelial P2Y(1) M receptor may mediate release of t-PA during ischemia and post-ischemic hyperemia, an effect that may counteract some of the platelet activating effects of ADP PMID:17294140