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Recombinant Pig Signal transducer and activator of transcription 2 (STAT2), partial

Recombinant Pig Signal transducer and activator of transcription 2 (STAT2), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

STAT2

Uniprot NO.

O02799

Alternative Names

STAT2; Signal transducer and activator of transcription 2

Species

Sus scrofa (Pig)

Source

Yeast

Expression Region

1-864

Target Protein Sequence

MAQWEMLQNL DSPFQDQLHQ LYSESLLPVD VRQYLAVWIE DQNWQEAALG NDDSKANMLF FHFLDQLNYD CGRCGQDPEC LLLQHNLRKF YRDIQAIPQG PTRLAEMIFN LLLEEKRILI QAQRAQLEQQ EPALEAPGEN QQHEIESRIL ELRAMMEKLV KSISQLKDQQ DIFCFRYKIK ASAKTHSLDP HRTRQEQVLQ ETLNELDKRR KEVLDASKAL LGRLTTLIEL LLPKLEEWKV QQQKACIGAP MDGELEQLEK WFTAEAKLLF HLRQLLKELK GLSSVVKYDE DLLFKGVDLL KAQVTELLQR LLHRAFIVET QPCMPQTPHR PLILKTGSKF TVRTRLLVRL QEGNESLTAE VSIDRNPPKS QGFRKFNILT SNRKTLTPEK GQSQGLIWDF GYLTLMEQRS GGAGKGNNKG PLGVTEELHI ISFTVKYTYQ GLKQELTTDT LPVVIISNMN QLSIAWASIL WFNLLSSDPQ NQQFFSSPPK APWNLLGPAL SWQFSSHVGQ GLNSDQLGML RDKLFGQNSS TEGLSLSWVD FIKRESPPGK LPFWTWLDKI LDLVHDHLKD LWKDGHIMGF VSRSEERRLL KKTISGTFLL RFSETLEGGI TCSWVEHQDD DKVLIYSLQP FTKEVLQSLP LTKIISQYQL LTEENIPENP LRFLYPRIPR DEAFGCYNQE KANLQERKKY LKHKLIVVSN RQVDELQQPP ELKLEPDLES LELDLGLAPG PEPGVGLDLE PLLEAGLDLG PELEPMLQST LEPVLEPILD EVLQGVPEPN LGPELKLEPI LEPVSQPVPE PDLPHDLRHL NTDEMQIFRN SMRIEEIMPN GDPLLASQNT NVDEACVFHR SHFYTDGPLI PSDY
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. Acts as a regulator of mitochondrial fission by modulating the phosphorylation of DNM1L at 'Ser-616' and 'Ser-637' which activate and inactivate the GTPase activity of DNM1L respectively.

Gene References into Functions

While La Piedad Michoacan Mexico Virus V protein does not affect the protein levels of STAT1 or STAT2, it does prevent the interferon-induced phosphorylation and nuclear translocation of STAT1 and STAT2 thereby inhibiting cellular responses to interferon alpha/beta. PMID:26546155
Taken together, results of these experiments describe for the first time a novel mechanism by which foot-and-mouth disease virus evolves to inhibit IFN signaling via blocking STAT1/STAT2 nuclear translocation. PMID:24554650
Nsp1beta inhibits interferon-activated STAT1/STAT2 signal transduction by inducing karyopherin-alpha1 degradation. PMID:23449802
the majority of the STAT1/STAT2/IRF9 (IFN regulatory factor 9) heterotrimers remained in the cytoplasm of PRRSV-infected cells, which indicates that the nuclear translocation of the heterotrimers was blocked PMID:20739522