Recombinant Pig Prothrombin (F2)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

Purity

>85% (SDS-PAGE)

Target Names

Uniprot NO.

Q19AZ8

Alternative Names

F2; Prothrombin; EC 3.4.21.5; Coagulation factor II) [Cleaved into: Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain]

Species

Sus scrofa (Pig)

Source

Yeast

Expression Region

44-623

Target Protein Sequence

ANSGFFE EMRKGNLERE CVEEQCSREE AYEALESPSE TDAFWAKYTA CESVRKSREK LVECLEGNCA EGLGMNYRGN ISVTRSGIEC QLWRSRYPHK PEVNSTMYPG ADLRENFCRN PDGSITGPWC YTTSPTVRRE ACSIPVCGQG RVTAELIPRS GGSTVNVSPP LETCVPERGR QYQGRLAVTS HGSPCLAWGS SQAKALSKDQ DFNPAVPLVE NFCRNPDGDQ EGAWCYVAGQ PGDFEYCDLD YCEEPVDEEV GDALGENADA AIEGRTTADD FQPFFNEKTF GAGEADCGLR PLFEKSSLED KTEKELFESY IEGRIVEGSD AEIGLAPWQV MIFRKSPQEL LCGASLISDR WVLTAAHCLL YPPWDKNFTE NDLLVRIGKH SRTRYERNIE KISMLEKIYI HPRYNWRENL DRDIALLKLR KPITFSDYIH PVCLPDKETA TKLLRAGYKG RVTGWGNLKE TWTTSASEVQ PSVLQVVNLP IVERLVCKAS TRIRITDNMF CAGYKPDEGK RGDACEGDSG GPFVMKSPFN NRWYQMGIVS WGEGCDRDGK YGFYTHVFRL KKWMQKVIDR FGG
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing.

Gene References into Functions

thrombin stimulates transglutaminase activity in articular cartilage by directly cleaving factor XIII and by receptor-mediated up-regulation of factor XIII synthesis PMID:14983233
The great similarity of prothrombin among rhesus, human, and porcine confirm the great value of the pig-to-rhesus xenotransplantation model. PMID:18374141
In conclusion, thrombin activates pro-MMP-2 in the absence of elevated pro-MMP-2 expression and secretion in CSMCs, and thrombin induces CSMC mitogenesis involving its action on MMP-2 PMID:19150392
Thrombin stimulates swine smooth muscle cell differentiation from peripheral blood mononuclear cells via protease-activated receptor-1, RhoA, and myocardin. PMID:19574550