Home
Product
Protein
Recombinant Proteins
Recombinant Pig Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A), partial

Recombinant Pig Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A), partial

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
Have Questions?	Leave a Message or Start an on-line Chat

Product Details
Related Products
Customer Reviews and Q&A
Target Background

Product Details

Abbreviation

PPARGC1A

Purity

>85% (SDS-PAGE)

Target Names

PPARGC1A

Uniprot NO.

Q865B6

Alternative Names

PPARGC1A; PGC1; PGC1A; PPARGC1; Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; PGC-1-alpha; PPAR-gamma coactivator 1-alpha; PPARGC-1-alpha

Species

Sus scrofa (Pig)

Source

Yeast

Expression Region

1-796

Target Protein Sequence

MAWDMCNQDS VWTDIECAAL VGEDQPLCPD LPELDLSELD VNDLDTDSFL GGLKWCSDQS EIISNQYNNE PSNIFEKIDE ENEANLLAVL TETLDSLPVD EDGLPSFDAL TDGDVTTENE ASPSSMPDGT PPPQEAEEPS LLKKLLLAPA NTQLSYNECS GLSTQNHANH NHRIRTNPAV VKTENSWSNK AKSICQQQKP QRRPCSELLK YLTTNDDPPH TKPTETRNSS RDKCTSKKKA HTQSQSQHLQ AKPTSLSLPL TPESPNDPKG SPFENKTIER TLSVELSGTA GLTPPTTPPH KANQDNPFRA SPKLKPPCKT VVPPPSKKTR YSESSGTHGN NSTKKGPEQS ELYAQLSKTS ALGGGHEERK ARRPSLRLFG DHDYCQSINS KAEILINISQ ELHDSRQLDS KDAASDWQRQ MCSSTDSDQC YLTETSEASR QVSPGSARKQ LQDQEIRAEL NKHFGHPSQA VFDDEADKTS ELRDSDFSNE QFSKLPMFIN SGLAMDGLFD DSEDESDKLN SPWDGTQSYS LFDVSPSCSS FNSPCRDSVS PPKSLFSQRP QRMRSRSRSF SQHRSCSRSP YSRSRSRSPG SRSSSRSCYY SESGHCRHRT HRNSPLCARS RSRSPYSRRP RYDSYEEYQH ERLKREEYRR EYEKRESERA KQRERQRQKA IEERRVIYVG KIRPDTTRTE LRDRFEVFGE IEECTVNLRD DGDSYGFITY RYTCDAFAAL ENGYTLRRSN ETDFELYFCG RKQFFKSNYA DLDSNSDDFD PASTKSKYDS LDFDSLLKEA QRSLRR
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

■ Customer Reviews

Submit a Review here

Target Background

Function(From Uniprot)

Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. Also involved in the integration of the circadian rhythms and energy metabolism. Required for oscillatory expression of clock genes, such as ARNTL/BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK.

Gene References into Functions

Study investigated the molecular basis of such effects focusing on a commonly studied polymorphism in pig Pgc1alpha, which changes a cysteine at position 430 (WT) of the protein to a serine (C430S); found that differential O-GlcNAcylation of Pgc1alpha regulates PCK1 activity and this molecular mechanism could explain at least in part the epistatic interaction between both genes. PMID:28644880
Transcription of the gene was detected in adipose, muscle, kidney, liver, brain, heart and adrenal gland tissues, which is in agreement with the function of PPARGC1A in adaptive thermogenesis. PMID:16276098
The purpose of this study was to screen for new single nucleotide polymorphisms in exon 8 of the porcine PPARGC1A gene and to test their possible association with production traits. PMID:17149556
impact of PPARGC1A on energy and lipid metabolism in vivo, through several downstream target genes PMID:19875886
Proliferator-activated receptor-gamma coactivator-1A p.C430S genotypes significantly affected number (P < 0.05) and area (P < 0.01) of type I muscle fibre, and were significantly associated with muscle pH (P < 0.001) and lightness(P < 0.01). PMID:20412126
The *2690T>C and *2864T>C polymorphisms in PPARGC1A can be used as genetic markers for selection toward improved meat quality. PMID:21748318
The c.-2894G>A polymorphism in the 5' upstream region of the porcine PPARGC1A gene can be used as a meaningful molecular marker for simultaneous improvement of lean meat production and quality traits. PMID:21769481
PPARGC1A may play a key role in down-regulating lipid deposition, and the SNPs with differential genotype distribution among three breeds may be related to gene expression and fat deposition. PMID:25004892
Polymorphisms in PPARGC1A and CAPNS1 genes may affect meat quality traits. PMID:21680104