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Recombinant Pig POU domain, class 5, transcription factor 1 (POU5F1)

Recombinant Pig POU domain, class 5, transcription factor 1 (POU5F1)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

POU5F1

Purity

>85% (SDS-PAGE)

Target Names

POU5F1

Uniprot NO.

Q9TSV5

Species

Sus scrofa (Pig)

Source

Yeast

Expression Region

1-360

Target Protein Sequence

MAGHLASDFA FSPPPGGGGD GPGGPEPGWV DPRTWLSFQG PPGGSGIGPG VGPGAEVWGL PACPPPYDFC GGMAYCAPQV GVGLVPQGGL ETPQPEGEAG AGVESNSEGA SPEPCAAPAG AAKLDKEKLE PNPEESQDIK ALQKDLEQFA KLLKQKRITL GYTQADVGLT LGVLFGKVFS QTTICRFEAL QLSFKNMCKL RPLLQKWVEE ADNNENLQEI CKAETLVQAR KRKRTSIENR VRGNLESMFL QCPKPTLQQI SHIAQQLGLE KDVVRVWFCN RRQKGKRSSS DYSQREDFEA AGSPFPGGPV SFPLAPGPHF GTPGYGGPHF TTLYSSVPFP EGEAFPSVSV TPLGSPMHSN
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 or SOX15 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency.

Gene References into Functions

Activin A and overexpression of SMAD2/3 significantly promoted expressions of porcine NANOG and OCT4,maintaining induced pluripotent stem cell self-renewal through up-regulation of Nanog/OCT4 expression. PMID:27996082
Our results indicate that continuous expression of OCT-4 in blastomeres is essential for trophectoderm formation of porcine embryos. PMID:27210587
These findings suggest that the 12-bp indel polymorphism of the Oct4 gene might be a potential DNA marker for selecting preferred individuals in relation to reproductive traits in pig marker-assisted selection breeding. PMID:28139300
Oct4-overexpression enhances porcine ovarian stem cell differentiation in to oocyte-like cells. PMID:27067537
showed novel molecular regulation of CDX2 on Oct4, and provided important clues for clarifying the mechanism of interaction between CDX2 and Oct4 in embryo of mammals other than mouse PMID:26708097
Overexpression of Sox2 or Oct4 in bone mesenchymal stem cells in culture media containing a basic fibroblast growth factor results in higher proliferation and differentiation compared to controls. PMID:24338401
Oct4 positive stem/progenitor swine lung epithelial cells are targets for influenza virus replication. PMID:22491467
study shows that localization of octamer-binding protein 4(OCT4) is associated with an embryonic stem cell (ESC)-like morphology from porcine inner cell mass PMID:20663092
OCT4 expression, in contrast to earlier speculations, at least in hatched blastocysts, resembles the expression pattern in the mouse embryo. PMID:21089074
cells isolated from umbilical cord express three transcription factors,Oct-4, Sox-2 & Nanog, found in pluripotent stem cell markers both at the mRNA and protein level. PMID:16460563
in the forming endoderm at the primitive streak stage, OCT4 was detectable in potential primordial germ cells only; in the ectoderm and mesodermal cell lineages OCT4 was cleared at the neural groove and somite stage, respectively PMID:16541449