Recombinant Pig Optineurin (OPTN), partial

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Target Background

Product Details

Abbreviation

OPTN

Purity

>85% (SDS-PAGE)

Target Names

OPTN

Uniprot NO.

Q7YS99

Species

Sus scrofa (Pig)

Source

Yeast

Expression Region

1-574

Target Protein Sequence

MSHQPLSCLT EKGDSPTETT GNGPPTLAHP NLDTFTPHEL LQQMRELLIE NHQLKEAMKL NNQAMKGRFE ELSAWTEKQK EERLFFETQS KEAKERLTAL SLENEKLKQE LGKLKGKTER SFEDLTGDPR VPKAEAEQEV EQLKTQVARL QAEKADLLGI VSELQLKLNS GGPSEDSFVE IRMAEGEADA AMKEIKTSPG PIRTDSIDTS KSAEGTRNYL EFEELTVSQL LLCLREGNQK VERLEIALKE AKERILDFEK KAKDRSETET QTEEHKEQEK EEEKSPETVG SEVEMLNLQV TTLFKELQEA HTKLSEAELM KKRLQEKCQA LERKNSATPS ELNEKQELLY NNKKLELQVE SMRSEIKMEQ AKTEEEKSKL TTLQLTHNRL LQEYNNALKT IEELKRRESE KVDKVVLQEL NGKLEMAEKA LASKQLQMDE MKQTIAKQEK DLETMAVLRA QMEVYCSDFH AERAAREKIH EEKEQLALQL AVLLKDDNAF EEGASRQSLM EMQSRHGARA SDADQQAFLV QRGAEDRNWL QQQQQNIPIH SCPKCGEVLP DIDTLLIHVT DCII
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD). Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as of transferrin receptor (TFRC/TfR); regulates Rab8 recruitnment to tubules emanating from the endocytic recycling compartment. Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family; targets ubiquitin-coated bacteria (xenophagy) and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52.

Subcellular Location

Cytoplasm, perinuclear region. Golgi apparatus. Golgi apparatus, trans-Golgi network. Cytoplasmic vesicle, autophagosome. Cytoplasmic vesicle. Recycling endosome.

Tissue Specificity

Present in aqueous humor of the eye (at protein level). Expressed in trabecular meshwork and astrocytes.

Database Links

UNIGENE: Ssc.51890

KEGG: ssc:397011

STRING: 9823.ENSSSCP00000025164

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