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Recombinant Pig Myeloid differentiation primary response protein MyD88 (MYD88)

Recombinant Pig Myeloid differentiation primary response protein MyD88 (MYD88)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

MYD88

Uniprot NO.

A2TF48

Alternative Names

MYD88; Myeloid differentiation primary response protein MyD88

Species

Sus scrofa (Pig)

Source

Yeast

Expression Region

1-293

Target Protein Sequence

MAAGGSGAES APPTPSMSSL PLAALNVRVR HRLSLFLNVR TQVAADWTGL AEEMNFEYLE IRRLETHPDP TRSLLDDWQG RPGASVGRLL ELLAKLGRDD VLVELGPSIE EDCRKYILKQ QQEAAEKPLQ VDSVDSSIPW MSGITIRDDP LGQMPEHFDA FICYCPSDIQ FVQEMIRQLE QTNYRLKLCV SDRDVLPGTC VWSIASELIE KRCRRMVVVV SDDYLQSKEC DFQTKFALSL SPGAHQKRLI PVKYKSMKKE FPSILRFITV CDYTNPCTKS WFWTRLARAL SLP
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. Upon TLR8 activation by GU-rich single-stranded RNA (GU-rich RNA) derived from viruses, induces IL1B release through NLRP3 inflammasome activation. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine.

Gene References into Functions

These results suggest that porcine circovirus 2 induces IL-8 secretion via the TLR2/MyD88/NF-kappaB signalling pathway. PMID:26581603
At 30 days after autotransplantation of a pig kidney, mRNA expression increases for MyD88. PMID:25380861
These results suggest that an MyD88-dependent signaling pathway is present in newborn as well as in adult swine and that it is involved in the innate immune system of these animals. PMID:17976317

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Subcellular Location

Cytoplasm. Nucleus.

Tissue Specificity

Expressed in esophagus, duodenum, jejenum, ileum, ileal Peyer patches, mesenteric lymph node, colon and spleen.

Database Links

UNIGENE: Ssc.23492

KEGG: ssc:396646

STRING: 9823.ENSSSCP00000011996

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