Recombinant Pig Mannose-binding protein C (MBL2)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

MBL2

Purity

>85% (SDS-PAGE)

Target Names

MBL2

Uniprot NO.

Q9XSW3

Alternative Names

MBL2; Mannose-binding protein C; MBP-C; 27 kDa mannan-binding protein monomeric subunit; pMBP-27; Mannose-binding lectin; MBL

Species

Sus scrofa (Pig)

Source

Yeast

Expression Region

19-240

Target Protein Sequence

HT ETENCEDIQN TCLVISCDSP GINGLPGKDG LDGAKGEKGE PGQGLIGLQG LPGMVGPQGS PGIPGLPGLK GQKGDSGIDP GNSLANLRSE LDNIKKWLIF AQGKQVGKKL YLTNGKKMSF NGVKALCAQF QASVATPTNS RENQAIQELA GTEAFLGITD EYTEGQFVDL TGKRVRYQNW NDGEPNNADS AEHCVEILKD GKWNDIFCSS QLSAVCEFPA
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. According to some authors, it only binds mannose.

Gene References into Functions

MBL2 polymorphisms were associated with some disease groups and with the presence of some etiologic agents PMID:17194476
MBL1 was also found to be expressed in the lung, testis and brain, whereas low expression of MBL2 was detected in the testis and kidney. PMID:17284229

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Subcellular Location

Secreted.

Tissue Specificity

Expressed in liver. Weakly expressed in kidney and testis.

Database Links

UNIGENE: Ssc.15845

KEGG: ssc:397230

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