Recombinant Pig Haptoglobin (HP)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Target Background

Product Details

Abbreviation

Purity

>85% (SDS-PAGE)

Target Names

Uniprot NO.

Q8SPS7

Alternative Names

HP; Haptoglobin [Cleaved into: Haptoglobin alpha chain; Haptoglobin beta chain]

Species

Sus scrofa (Pig)

Source

Yeast

Expression Region

19-347

Target Protein Sequence

AE TGNEATDATD DSCPKPPEIP KGYVEHMVRY HCQTYYKLRT AGDGVYTLDS NKQWTNKVTG EKLPECEAVC GKPKNPVDQV QRIMGGSLDA KGSFPWQAKM ISHHNLTSGA TLINEQWLLT TAKNLRLGHK NDTKAKDIAP TLRLYVGKKQ EVEIEKVIFH PDNSTVDIGL IKLKQKVPVN ERVMPICLPS KDYVNVGLVG YVSGWGRNAN LNFTEHLKYV MLPVADQEKC VQYYEGSTVP EKKTPKSPVG VQPILNEHTF CAGLSKYQED TCYGDAGSAF AVHDKDDDTW YAAGILSFDK SCRTAEYGVY VRVTSILDWI QTTIADN
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway.

Gene References into Functions

crystal structure of the dimeric porcine haptoglobin-haemoglobin complex determined at 2.9 A resolution PMID:22922649
This protein is elevated in porcine postweaning multisystemic wasting syndrome. PMID:15210076
haptoglobin has a role in oxidative status in piglets undergoing weaning-induced stress PMID:16438801
This study suggested closer links between the release of haptoglobin, Pig-MAP and monocytes compared to the release of AGP, SAA and transthyretin. PMID:17629575
The haptoglobin was down-regulated with SNPs PMID:18777092
Presence of haptoglobin alpha 1S subunit is a reponse to respiratory syndrome virus infection. PMID:18931071