Recombinant Pig Fatty acid-binding protein, adipocyte (FABP4)

Code
MSDS
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
FABP4
Uniprot NO.
Species
Sus scrofa (Pig)
Source
Yeast
Expression Region
2-132
Target Protein Sequence
CDAFVGTWK LVSSENFDDY MKEVGVGFAT RKVAGMAKPN LIITVNGDMI TIRSESTFKN TEIAFKLGQE FDEVTADDRK VKSTITLDGG ALVQVQKWDG KTTTINRKIV DDKLVVECIM KGVTATRIYE RA
Protein Length
Full Length of Mature Protein
Tag Info
N-terminal His-tagged/Tag-Free
Storage
Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Description

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Target Background

Function
Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus. Involved in the regulation of intramuscular fat accretion.
Gene References into Functions
  1. FABP4 gene expression level in adipose tissue was higher than in muscle. In contrast, FABP5 was expressed at low levels in adipocytes and muscle tissues. Low and moderate correlations between FABP4 and FABP5 gene expression were observed in muscle and in backfat, respectively. PMID:29076225
  2. the A-FABP gene is strongly related to the development and function of intramuscular fat accretion in pigs. PMID:23135696
  3. AFABP is significantly increased in coronary artery in-stent restenosis segments of both diabetic and nondiabetic minipigs. PMID:23372061
  4. Thus A-FABP may be a candidate gene or a quantitative trait locus-linked gene associated with meat quality traits. PMID:21846497
  5. Monitoring of posttransplant L-FABP plasma levels is a valuable new tool to quantify early the extent of parenchymal cell damage of non-heart-beating donors in liver transplantation. PMID:15808662
  6. study suggests that FABP-4 protein content may be a valuable marker of lipid accretion PMID:16612010
  7. A study of the mapping characteristics and relationship to body composition of FAT1 and FABP4 in swine is reported. PMID:17032783
  8. regenerated coronary endothelial cells exhibit upregulation of adipocyte fatty acid binding protein (A-FABP) PMID:17942849

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Subcellular Location
Cytoplasm. Nucleus.
Protein Families
Calycin superfamily, Fatty-acid binding protein (FABP) family
Tissue Specificity
Adipose tissue.
Database Links

UNIGENE: Ssc.1089

KEGG: ssc:399533

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