Recombinant Pig Estrogen receptor (ESR1), partial

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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

ESR1

Uniprot NO.

Q29040

Species

Sus scrofa (Pig)

Source

Yeast

Expression Region

1-595

Target Protein Sequence

MTMTLHTKAS GMALLHQIQA NELEPLNRPQ LKIPLERPLG EVYVDSSKPA VYNYPEGAAY DFNAAAAASA PVYGQSGLAY GPGSEAAAFG ANGLGGFQPL NSVSPSPLVL LHPPPQLSPF LHPHGQQVPY YLENEPSGYA VREAGPPAFY RPNSDNRRQG GRERLASTSD KGSMAMESAK ETRYCAVCND YASGYHYGVW SCEGCKAFFK RSIQGHNDYM CPATNQCTID KNRRKSCQAC RLRKCYEVGM MKGGIRKDRR GGRMLKHKRQ RDDGEGRNEA VPPGDMRSAN LWPSPLLIKH TKKNSPVLSL TADQMISALL EAEPPIIYSE YDPTRPLSEA SMMGLLTNLA DRELVHMINW AKRVPGFLDL SLHDQVHLLE CAWLEILMIG LVWRSMEHPG KLLFAPNLLL DRNQGKCVEG MVEIFDMLLA TSSRFRMMNL QGEEFVCLKS IILLNSGVYT FLSSTLKSLE EKDHIHRVLD KITDTLIHLM AKAGLTLQQQ HRRLAQLLLI LSHFRHMSNK GMEHLYNMKC KNVVPLYDLL LEMLDAHRLH APTNLGGPPP EDMSQSQLAT SGSTPSHSLQ MYYITGEAEN FPTTI

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Description

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Target Background

Function

Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades.Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3.

Gene References into Functions

These results will improve the understanding of the functions of the ESR1 in spermatogenesis within the reproductive tract and will shed light on ESR1 as a candidate in the selection of boar with good sperm quality and fertility. PMID:21944540
study is the first one to demonstrate the presence of estrogen receptors alpha and beta in the porcine uterus not only at the beginning but also at mid- and late pregnancy PMID:19645857
findings suggest that testicular estrogen receptors alpha and beta may be important factors contributing to onset and maintenance of spermatogenesis in the boar. PMID:15943697
Results showed that the effects of FSHb, ESR, and PRLR genes were significant in the Tibet pig population, and the effective genotypes of the three genes for reproductive traits were BB, BB, and AA, respectively. PMID:20466637
The aim of this work was to study the effects on litter size of variants of the porcine genes RBP4, ESR1 and IGF2, currently used in genetic tests for different purposes. PMID:20576168
ERalpha mRNA was present in type A and type B spermatogonia up to mid-pachytene primary spermatocytes in stage V-VIII and stage I of the seminiferous epithelial cycle, but not in other cells. PMID:16249893
positive staining for ERalpha in the nuclei of skeletal muscle cells, while the ERbeta stain showed positive signals in nuclei and cytoplasm of skeletal myofibers and myoblasts derived from satellite cells PMID:16897031
The objective of this study was to search for polymorphisms in the coding region of the estrogen receptors 1 and 2 (ESR1 and ESR2) and to analyze the effects of these variants and the well known intronic ESR1 PvuII polymorphism on litter size. PMID:17306201
These data demonstrate novel and differential mechanisms by which ERalpha and ERbeta activation control coronary artery vasoreactivity in males and females and regulate vascular NO and O(2)(-) formation. PMID:17470727
Pig ejaculated spermatozoa express estrogen receptor. PMID:17553131
The expression of mRNAs for ERalpha, ERbeta and PR in the sow uterus differed between endometrium and myometrium as well as with stages of the estrous cycle and early pregnancy. PMID:18547755