Recombinant Pig Dystrophin (DMD), partial

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Target Background

Product Details

Abbreviation

DMD

Purity

>85% (SDS-PAGE)

Target Names

DMD

Uniprot NO.

Q5GN48

Alternative Names

DMDDystrophin

Species

Sus scrofa (Pig)

Source

Yeast

Expression Region

1-3674

Target Protein Sequence

MSEVSSDERE DVQKKTFTKW INAQFSKFGK QHIENLFNDL QDGRRLLDLL EGLTGQKLPK EKGSTRVHAL NNVNKALQVL QKNNVDLVNI GSTDIVDGNH KLTLGLIWNI ILHWQVKNVM KNIMAGLQQT NSEKILLSWV RQSTRNYPQV NVINFTTSWS DGLALNALIH SHRPDLFDWN SVVCQQSATQ RLEHAFNIAK YQLGIEKLLD PEDVATTYPD KKSILMYVTS LFQVLPQQVS IEAIQEVEML PRPSKVTREE HFQLHHQMHY SQQITVCLAQ GYERTPSPKP RFKSYAYTQA AYVTTSDPTR SPFPSQRLES PEDKSFGSSL LETEVNLDSY QTALEEVLSW LLSAEDTLQA QGEISNDVEE VKEQFHTHEG YMMDLTSHQG RIGSVLQLGS QLIGKGKLSE DEETEVQEQM NLLNSRWECL RVASVEKQSN LHKVLMDLQN QQLKELNDWL TKTEEKTRKM EKEPLGPDLE DLKHQIQQHK VLQEDLEQEQ VRVNSLTHMV VVVDESSGDH ATAALEEQLK VLGDRWANIC RWTEDRWVLL QDILLKWQRF TEEQCLFSTW LSEKEDALNK IHTTGFKDQG EMLSSLQKLA VLKTDLEKKK QTMDKLSSLN QDLLSTLKNT LVAQKMEAWL DNFAQRWDNL VQKLEKSSTQ ISQAVTTTQP SLTQTTVMET VTMVTTREQI LVKHAQEELP PPPPQKKRQI IVDSEIRKRL DVDITELHSW ITRSEAVLQS PEFAIYRKEG NFSDLKEKVN AIEREKAEKF RKLQDASRSA QALVEQMVNE GVNADSIKQA AEQLNSRWIE FCQLLSERLN WLEYQNRIIT FYNQLQQLEQ ITTAAENWLK TQPITTSEPT AVKSQLKICK DEVNRLSALQ PQIERLKIES IALKEKGQGP MFLDADSVAF TNHFNQVFAD MQAKEKELQI IFDTLPPMRY QETMSTILTW IQHSEAKLSI PQATVTEYEI MEQRLGELQA LQSSLQEQQN GLNYLSTTVK EMSKKAPSNI SRKYQSEFEE IEGRWKKLSA QLMEHCQKLE EQIAKLRKLQ NHIKTLKNWM AEVDIFLKEE WPALGDSEIL RKQLKQCRLL VSDIQTIQPS LNSVNEGGQK IKKEAEPEFA SRLETELREL NTQWDYICRQ VYARKEALKG GLDKTISLQK DLSEMHEWMT QAEEEYLERD FEYKTPDELQ TAVEEMKRAK EEAQQKEAKV KLLTESVNSV IAQAPPAAQE ALKKELDTLT TNYQWLCTRL NGKCKTLEEV WACWHELLSY LEKANKWLSE VEFKLKTTEN IPGGAEEISE VLESLENLMQ HSEDNPNQIR ILAQTLTDGG VMDELINEEL ETFNSRWREL HEEAVRRQKL LEQSIQSAQE IEKSLHLIQD SLSSIDHQLA VYIADKVDAA QMPQEAQKIQ SDLTSHEISL EEMKKHYQGK EAAPRVLSQI ELAQKKLQDV SMKFRLFQKP ANFEQRLQES KMILDEVKMH LPALEIKSVE QEVVQSQLNH CVNLYKSLSE VKSEVEMVIK TGRQIVQKKQ TENPKELDER VTALKLHYNE LGAKVTERKQ QLEKCLKLSR KMRKEMNVLT EWLAATDTEL TKRSAVEGMP SNLDSEVVWG KATQKEIEKQ KFHLKSISEI GEALKMVLGK KETLVEDKLS LLNSNWIAVT SRAEEWLNLL LEYQKHMENF DQNVDHITKW IIQADTLLDE SEKKKPQQKE DVLKRLKAEM NDMRPKVDST RDQAANLMAN RGDHCRKVIE PKISELNHRF AAISHRIKTG KASIPLKELE QFNSDIQKLL EPLEAEIQQG VNLKEEDFNK DMSEDNEGTV KELLQRGDNL QQRITDERKR EEIKIKQQLL QTKHNALKDL RSQRRKKALE ISHQWYQYKR QADDLLKCLD DIEKKLASLP EPQDEKKIKE IDRELQKKKE ELDAVRRQAE GLSEDGAAMA VEPTQIQLSK RWREIESKFA HFRRLNFAQI HTVHEESVMV MTEDMPLEIS YVPSAYLTEI THVSQALSEV EQLLNAPDLC AKDFEDLFKQ EESLKNIKDS LQQISGRVDI IHNKKTAGLQ SATPVERTRL QEALSQLDFQ WERVNKMYKD RQGKFDRSVE KWRRFHYDMK IFNQWLTEAE HFLKKTQIPE NWEHAKYKWY LKELQDGIGQ RQTIVRVLNA TGEEVIQQSS KTDASILQEK LGSLNLRWQE VCKQLAERKK RLEEQKNILS EFQRDLNEFV LWLEEADNIT SVALEPGNEQ QLKEKLEEIK LLAEELPLRQ GTLKQLNETG GTVLVSAPIS PEEQDKIENK LKQTNLQWIK VSRILPEKQG EIEAHIKDLG QFEEQLNHLL VWLSPIKNQL EIYNQPNQTG PFDIKETEVA VQAKQLDVEG ILSKGQHLYK EKPATQPVKR KLEDLSSEWK AVTHLLQELR AKWPGPTPGL TTIEAPTSQT VTLVTQPTVT KETAISKPEM PSSLLLEVPA LADFNRAWTE LTDWLSLLDR VIKSQRVMVG DLEDINEMII KQKATLQDLE QRRPQLEELI TAAQNLKNKT SNQEARTIIT DRIERIQSQW DEVQEHLQNR RQQLNEMLKD STQWLEAKEE AEQVLGQARA KLESWKEGPY TMDAIQRKIT ETKQLAKDLR QWQINVDVAN DLALKLLRDY SADDTRKVHM ITENINASWA NIHKRLSERE TVLEETHRLL QQFPLDLEKF LAWLTEAETT ANVLQDATHK ERLLEDSKGV RELMKQWQDL QGEIEAHTDI YHNLDENGQK ILRSLEGSDD AILLQRRLDN MNFKWSELRK KSLNIRSHLE ASSDQWKRLH LSLQELLVWL QLKDDELSRQ APIGGDCPAV QKQNDVHRAF KRELKTKEPV IMSTLETVRI FLTEQPLEGL EKLYQEPREL PPEERAQNVT RLLRKQAEEV NTEWEKLNLH SADWQRKIDE ALERLQELQE ATDELDLKLR QAEVIKGSWQ PVGDLLIDSL QDHLEKVKAL RGEKAPLKEN VSHVNDLARQ LTTLGIQLSP YNLSTLEDLN TRWKLLQVAV EDRIRQLHEA HRDFGPASQH FLSTSVQGPW ERAISPNKVP YYINHETQTT CWDHPKMTEL YQSLADLNNV RFSAYRTAMK LRRLQKALCL DLLSLSAACD ALDQHNLKQN DQPMDILQII NCLTTVYDRL EQEHNNLVNV PLCVDMCLNW LLNVYDTGRT GRIRVLSFKT GIVSLCKAHL EDKYRYLFKQ VASSTGFCDQ RRLGLLLHDS IQIPRQLGEV ASFGGSNIEP SVRSCFQFAN NKPEIEAALF LDWMRLEPQS MVWLPVLHRV AAAETAKHQA KCNICKECPI IGFRYRSLKH FNYDICQSCF FSGRVAKGHK MHYPMVEYCT PTTSGEDVRD FAKVLKNKFR TKRYFAKHPR MGYLPVQTVL EGDNMETPVT LINFWPVDSA PASSPQLSHD DTHSRIEHYA SRLAEMENSN GSYLNDSISP NESIDDEHLL IQHYCQSLNQ DSPLSQPRSP AQILISLESE ERGELERILA DLEEENRNLQ AEYDRLKQQH EHKGLSPLPS PPEMMPTSPQ SPRDAELIAE AKLLRQHKGR LEARMQTLED HNKQLESQLH RLRQLLEQPQ AEAKVNGTTV SSPSTSLQRS DSSQPMLLRV VGSQTSESMG EEDLLSPPQD TSTGLEEVME QLNNSFPSSR GRNTPGKPVR EDTM
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Anchors the extracellular matrix to the cytoskeleton via F-actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission.

Gene References into Functions

Data indicate that skeletal muscles from with a missense mutation in the dystrophin gene is associated with muscle histophatology. PMID:24347611
This study suggested thatdystrophins are expressed in the outer plexiform layer, around blood vessels and at the inner limiting membrane as previously described in human and mouse retinae. PMID:15941659

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Subcellular Location

Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell junction, synapse, postsynaptic cell membrane.

Tissue Specificity

In the retina, expressed in the outer plexiform layer (OPL) and around the blood vessels. Also observed at the vitreal border of the retina corresponding to the inner limiting membrane (ILM). Presynaptically localized in cone pedicles and postsynaptically

Database Links

UNIGENE: Ssc.42754

KEGG: ssc:497636

STRING: 9823.ENSSSCP00000030238

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