Recombinant Pig Chromogranin-A (CHGA)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

CHGA

Uniprot NO.

P04404

Alternative Names

CHGAChromogranin-A; CgA) [Cleaved into: Pancreastatin; Parastatin; WE-14; Catestatin; GE-25; Serpinin-RRG; Serpinin; p-Glu serpinin precursor]; Fragment

Species

Sus scrofa (Pig)

Source

Yeast

Expression Region

17-446

Target Protein Sequence

LPVN SPMNKGDTEV MKCIVEVISD TLSKPSPMPV SQECFETLRG DERILSILRH QNLLKELQDL ALQGAKERSH QQKKQSSYED ELSEVLEKQN DQAELKEGTE EASSKEAAEK RGDSKEVEKN DEDADGAKPQ ASLEPPXXXE AEDQTPGEEE AASTHPLASL PSKKRPGAQA EEDHEGPSQG PVDREKGPSA EQGPQAEREE EEEAEAGEKA VPEEEGPRSE AFDSHPSLGY KEMQRGWPQA PAMDGAGKTG AEEAQPPEGK GAREHSRQEE EEETAGAPQG LFRGGKRGEP AQEEEERLSE EWENAKRWSK MDRLAKELTA EKRLQGEEEE EEEEEDPDRS MKLSFRAPAY GFRGPGLQLR RGWRPSSRED SVEAGLPLQV RXYLEEKKEE EGSANRRPED QELESLSAIE AELEKVAPQL QSLRRG
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Strongly inhibits glucose induced insulin release from the pancreas.; Inhibits low calcium-stimulated parathyroid cell secretion.; Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist. Can induce mast cell migration, degranulation and production of cytokines and chemokines.; Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation.

Gene References into Functions

High pancreastatin levels are significantly associated with neuroendocrine tumors. PMID:24752611
No circadian pattern was detected for salivary CgA in either spring or autumn, and there were no significant effects of gender or age. However, mean salivary CgA concentrations were significantly higher in the pigs sampled in autumn, compared to spring. PMID:24507880
expression and localization of chromogranin A (CgA), chromogranin B (CgB), synaptophysin, and insulin were ultrastructurally studied with the immunogold technique in porcine and human pancreatic islet neuroendocrine cells PMID:12826904

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Subcellular Location

[Serpinin]: Secreted. Cytoplasmic vesicle, secretory vesicle.; Cytoplasmic vesicle, secretory vesicle. Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle. Secreted.

Protein Families

Chromogranin/secretogranin protein family

Database Links

UNIGENE: Ssc.4653

KEGG: ssc:397540

STRING: 9823.ENSSSCP00000002657

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