Recombinant Pig Caveolin-1 (CAV1)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

CAV1

Purity

>85% (SDS-PAGE)

Target Names

CAV1

Uniprot NO.

Q6RVA9

Species

Sus scrofa (Pig)

Source

Yeast

Expression Region

2-178

Target Protein Sequence

SGGKYVDSE GHLYTVPIRE QGNIYKPNNK AMAEEMNEKQ VYDAHTKEID LVNRDPKHLN DDVVKIDFED VIAEPEGTHS FDGIWKASFT TFTVTKYWFY RLLSALFGIP MALIWGIYFA ILSFLHIWAV VPCIKSFLIE IQCISRVYSI YVHTFCDPLF EAIGKIFSNI RINMQKEI
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation.

Gene References into Functions

Caveolin-1 is a modulator of fibroblast activation and a potential biomarker for gastric cancer PMID:25798057
transcription factor Sp1 interacts with nucleotides -123/-114, indicating that Sp1 could play a key role in the transcriptional regulation of pig CAV-1 PMID:21631282
Two alternative transcript variants encode two isoforms, caveolin-1-alpha and -beta; Cav1 may be implicated in pathogenesis of Glasser's disease of swine. PMID:21282513
The plasma membrane Na/K-ATPase-caveolin-1 interaction may represent an important sensing mechanism by which the cells regulate the sterol regulatory element-binding protein pathway. PMID:19363037
The present study indicates that caveolin-containing rafts/caveolins such as caveolin-1 could play a modulating role during oligodendroglial differentiation and regeneration via NGF/TrkA signaling. PMID:19795378
Cav-1 might be a candidate gene for carcass traits, and might provide valuable information for understanding the mechanism of caveolae signaling in fat deposition by using the animal model of pig PMID:18622749

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Subcellular Location

Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Membrane raft.

Protein Families

Caveolin family

Database Links

UNIGENE: Ssc.12842

KEGG: ssc:404693

STRING: 9823.ENSSSCP00000017622

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