Recombinant Pig C-C motif chemokine 2 (CCL2)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

CCL2

Uniprot NO.

P42831

Alternative Names

CCL2; SCYA2C-C motif chemokine 2; Monocyte chemoattractant protein 1; Monocyte chemotactic protein 1; MCP-1; Small-inducible cytokine A2

Species

Sus scrofa (Pig)

Source

Yeast

Expression Region

24-99

Target Protein Sequence

QPDAINS PVTCCYTLTS KKISMQRLMS YRRVTSSKCP KEAVIFKTIA GKEICAEPKQ KWVQDSISHL DKKNQTPKP
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Acts as a ligand for C-C chemokine receptor CCR2. Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions. Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils. Plays an important role in mediating peripheral nerve injury-induced neuropathic pain. Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B.

Gene References into Functions

these results provide novel insights into CCL2-mediated signaling mechanisms in the porcine endometrium at the maternal-fetal interface during early pregnancy PMID:29278679
CXCL10 protein was detected in serum from pigs infected with a high virulence African swine fever virus isolate. Levels of CCL2 mRNA were increased in pigs infected with the high virulence isolate compared to a low virulence isolate. PMID:24083897
Porcine CCL2 binding on Tuk4+SLA-II- but not on Tuk4-SLA-II+ cells was detected by using a CCL2-green fluorescence protein fusion protein. PMID:20670605
The protective properties of flavonoids, such as EGCG, against endothelial inflammation may be regulated in part though induction of HO-1 and subsequent activator protein-1 signaling. PMID:20580034
MCP-1 contributes to functional and structural impairment in the kidney in renal artery stenosis, mainly in the tubulointerstitial compartment PMID:19730125
may contribute to xenograft rejection by attracting monocytes into the islets PMID:14962280
Contrast media did not affect bone marrow cell viability/MCP-1 secretion. PMID:15274157
Porcine vessel wall injury via balloon arthroplasty upregulates expression of CCL2 by coronary artery transmural and perivascular cells in a sequential pattern. PMID:16926016
in the aortic arch expression of monocyte chemoattractant protein 1 (MCP-1) was upregulated, compared with the thoracic aorta PMID:17588585
Variable gene expression (eg, matrix metalloproteinase-9, CCL2 and Lp-PLA(2) mRNAs), both in regard to the arterial bed and duration of disease, was associated with variable plaque development and progression. PMID:18276914
myocardial infarction induced proinflammatory gene and protein expression in peripheral blood mononuclear cells of tissue factor cyclo-oxygenase-2, monocyte chemoattractant protein-1 and CRP PMID:19036073