Recombinant Pig Angiopoietin-2 (ANGPT2)

Baculovirus
Mammalian cell

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

ANGPT2

Purity

>85% (SDS-PAGE)

Target Names

ANGPT2

Uniprot NO.

Q9BDY7

Alternative Names

ANGPT2Angiopoietin-2; ANG-2

Species

Sus scrofa (Pig)

Source

Yeast

Expression Region

19-496

Target Protein Sequence

YN NFRKSMDSTG KRQYQVQHGP CSYTFLLPET DNCRSPSSSY VSNAVQRDAP LDYDDSVRRL QVLENIMENN TQWLMKLESY IQDNMKKEMV EIQQNAVQNQ TAVMIEIGTN LLNQTAEQTR KLTDVEAQVL NQTTRLELQL LEHSLSTNKL EKQILDQTSE INKLQDKNSF LEKKVLDMED KHIVQLQSIK EEKDQLQVLV SKQNSIIEEL EKQLVTATVN NSVLQKQQHD LMETVHNLLT MISTSNSAKH SLVAKEEQII FRDCAEAFKS GLTTSGTYTL TFPNSTEETK AYCDMETGGG GWTVIQRRED GSVDFQRTWK EYKMGFGSPS GEHWLGNEFV SQVTNQKRYV LKIHLRDWEG NEAYSLYEHF YLSSEEFNYR IHLKGLTGTA GKISSISQPG NDFSTKDADN DKCICKCSQM LTGGWWFDAC GPSNLNGMYY PQRQNTNKFN GIKWYYWKGS GYSLKATTMM IRPADF
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating angiogenic signals mediated by ANGPT1. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.

Gene References into Functions

expression of angiopoietin 2 in the porcine metanephric kidney was observed in the podocytes of early developing glomeruli, but not in the cells near the glomerular hilus PMID:20598355
ANGPT2 remained upregulated during maturation of glomeruli, which may be explained by the continuous growth of the glomeruli, as observed by stereological examination. PMID:20713984

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Subcellular Location

Secreted.

Database Links

UNIGENE: Ssc.240

KEGG: ssc:396730

STRING: 9823.ENSSSCP00000016694

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