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Recombinant Pan troglodytes Rho-associated protein kinase 1 (ROCK1), partial

Recombinant Pan troglodytes Rho-associated protein kinase 1 (ROCK1), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

ROCK1

Uniprot NO.

P61584

Alternative Names

ROCK1; Rho-associated protein kinase 1; EC 2.7.11.1; Rho-associated; coiled-coil-containing protein kinase 1; Rho-associated; coiled-coil-containing protein kinase I; ROCK-I; p160 ROCK-1; p160ROCK; Fragment

Species

Pan troglodytes (Chimpanzee)

Source

Yeast

Expression Region

1-1003

Target Protein Sequence

VAPVVPDLSS DIDTSNFDDL EEDKGEEETF PIPKAFVGNQ LPFVGFTYYS NRRYLSSANP NDNRTSSNAD KSLQESLQKT IYKLEEQLHN EMQLKDEMEQ KCRTSNIKLD KIMKELDEEG NQRRNLESTV SQIEKEKMLL QHRINEYQRK AEQENEKRRN VENEVSTLKD QLEDLKKVSQ NSQLANEKLS QLQKQLEEAN DLLRTESDTA VRLRKSHTEM SKSISQLESL NRELQERNRI LENSKSQTDK DYYQLQAILE AERRDRGHDS EMIGDLQARI TSLQEEVKHL KHNLEKVEGE RKEAQDMLNH SEKEKNNLEI DLNYKLKSLQ QRLEQEVNEH KVTKARLTDK HQSIEEAKSV AMCEMEKKLK EEREAREKAE NRVVQIEKQC SMLDVDLKQS QQKLEHLTGN KERMEDEVKN LTLQLEQESN KRLLLQNELK TQAFEADNLK GLEKQMKQEI NTLLEAKRLL EFELAQLTKQ YRGNEGQMRE LQDQLEAEQY FSTLYKTQVK ELKEEIEEKN RENLKKIQEL QNEKETLATQ LDLAETKAES EQLARGLLEE QYFELTQESK KAASRNRQEI TDKDHTVSRL EEANSMLTKD IEILRRENEE LTEKMKKAEE EYKLEKEEEI SNLKAAFEKN INTERTLKTQ AVNKLAEIMN RKDFKIDRKK ANTQDLRKKE KENRKLQLEL NQEREKFNQM VVKHQKELND MQAQLVEECA HRNELQMQLA SKESDIEQLR AKLLDLSDST SVASFPSADE TDGNLPESRI EGWLSVPNRG NIKRYGWKKQ YVVVSSKKIL FYNDEQDKEQ SNPSMVLDID KLFHVRPVTQ GDVYRAETEE IPKIFQILYA NEGECRKDVE MEPVQQAEKT NFQNHKGHEF IPTLYHFPAN CDACAKPLWH VFKPPPALEC RRCHVKCHRD HLDKKEDLIC PCKVSYDVTS ARDMLLLACS QDEQKKWVTH LVKKIPKNPP SGFVRASPRT LSTRSTANQS FRKVVKNTSG KTR
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress. Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Required for centrosome positioning and centrosome-dependent exit from mitosis. Plays a role in terminal erythroid differentiation. May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles. Promotes keratinocyte terminal differentiation. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization.

Subcellular Location

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Golgi apparatus membrane; Peripheral membrane protein. Cell projection, bleb. Cytoplasm, cytoskeleton. Cell membrane. Cell projection, lamellipodium. Cell projection, ruffle.

Protein Families

Protein kinase superfamily, AGC Ser/Thr protein kinase family

Database Links

STRING: 9598.ENSPTRP00000016847

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