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Recombinant Pan paniscus B-cell receptor CD22 (CD22)

Recombinant Pan paniscus B-cell receptor CD22 (CD22)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

CD22

Purity

>85% (SDS-PAGE)

Target Names

CD22

Uniprot NO.

Q9N1E5

Species

Pan paniscus (Pygmy chimpanzee) (Bonobo)

Source

Yeast

Expression Region

20-332

Target Protein Sequence

D SSKWAFEHPE TLYAWEGACV WIPCTYRALD RDLESFILFH NPEYNKNTSK FDGTRLYEST EDGKVPSEQK RVQFLGDKNK NCTLSIHPVH VNDSGQLGLR MESKTAKWME RIHLNVSERP FPPHIQLPPE IQESQEVTLT CLLNFSCYGY PIQLQWLLEG VPMRQAAVTS TSLTIKSVFT RSELKFSPQW SHHGKIVTCQ LQDADGKFLS NDTVQLNVKH TPKLEIKVTP SDAIVREGES VTMTCEVSSS NPEYTTISWL KDGTSLKKQN TLMLNLHEVT KDQSGKYCCQ VSNDVGPGRS AEVFLQVQYA PE
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Extracellular domain

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. Upon ligand-induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling cascade key molecules.

Subcellular Location

Cell membrane; Single-pass type I membrane protein.

Protein Families

Immunoglobulin superfamily, SIGLEC (sialic acid binding Ig-like lectin) family

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