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Recombinant Oryzias latipes Cellular tumor antigen p53 (tp53)

Recombinant Oryzias latipes Cellular tumor antigen p53 (tp53)

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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

tp53

Uniprot NO.

P79820

Species

Oryzias latipes (Japanese rice fish) (Japanese killifish)

Source

Yeast

Expression Region

1-352

Target Protein Sequence

MDPVPDLPES QGSFQELWET VSYPPLETLS LPTVNEPTGS WVATGDMFLL DQDLSGTFDD KIFDIPIEPV PTNEVNPPPT TVPVTTDYPG SYELELRFQK SGTAKSVTST YSETLNKLYC QLAKTSPIEV RVSKEPPKGA ILRATAVYKK TEHVADVVRR CPHHQNEDSV EHRSHLIRVE GSQLAQYFED PYTKRQSVTV PYEPPQPGSE MTTILLSYMC NSSCMGGMNR RPILTILTLE TEGLVLGRRC FEVRICACPG RDRKTEEESR QKTQPKKRKV TPNTSSSKRK KSHSSGEEED NREVFHFEVY GRERYEFLKK INDGLELLEK ESKSKNKDSG MVPSSGKKLK SN

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free

Storage

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Description

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Target Background

Function

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.

Gene References into Functions

p53 is not essential for tissue self-renewal in developing brain. PMID:26410759
These results suggest that p53 positively regulates neurogenesis via cell proliferation. PMID:22659737

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Subcellular Location

Cytoplasm. Nucleus.

Protein Families

P53 family

Database Links

UNIGENE: Ola.4812

KEGG: ola:100049321

STRING: 8090.ENSORLP00000008029

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