Home
Product
Protein
Recombinant Proteins
Recombinant Oncorhynchus mykiss Interleukin-6 (il6)

Recombinant Oncorhynchus mykiss Interleukin-6 (il6)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
Have Questions?	Leave a Message or Start an on-line Chat

Product Details
Related Products
Customer Reviews and Q&A
Target Background

Product Details

Abbreviation

il6

Purity

>85% (SDS-PAGE)

Target Names

il6

Uniprot NO.

Q0GGL7

Alternative Names

il6Interleukin-6; IL-6

Species

Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)

Source

Yeast

Expression Region

21-219

Target Protein Sequence

NPVPSALAEL MTSGWTSGEE LGTDGETGAP PKWEKMIKML VHEVTTLRNQ QFVEEFQKPV EEISSFSQHQ VPSTPPHLSK TLCSASNKEA CLQEISRGLQ VYQLLLQHVK AEYPQSTLLP SVTHQTTVLI GLVKDQMKVA EVVEDLSASE RKRVLGEVST GTEWERKTSV HAILRELRNF LVDTKRALRR MGKRGKDFQ
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

■ Customer Reviews

Submit a Review here

Target Background

Function(From Uniprot)

Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway. The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells.

Gene References into Functions

The results reveal that, in trout, IL-6 is a differentiation factor for B cells, stimulating IgM responses in the absence of follicular structures, and suggest that it was after follicular structures appeared that this cytokine evolved to modulate T-dependent responses within the germinal centers. PMID:27481356
IL6 mRNA abundance was significantly increased in spleen, liver, and gill of rainbow trout after experimental infection with Aeromonas salmonicida. PMID:25549935
in this paper we present for the first time in fish the functional characterisation of IL-6, using rainbow trout PMID:21704380
found that peptidoglycans derived from Gram-negative bacteria (Escherichia coli 0111:B4 and K12), are potent inducers of IL-1beta and IL-6 gene expression and were equal to, or more potent than, crude LPS. PMID:20304498