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Recombinant Oncorhynchus mykiss Cellular tumor antigen p53 (tp53)

Recombinant Oncorhynchus mykiss Cellular tumor antigen p53 (tp53)

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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

tp53

Uniprot NO.

P25035

Species

Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)

Source

Yeast

Expression Region

1-396

Target Protein Sequence

MADLAENVSL PLSQESFEDL WKMNLNLVAV QPPETESWVG YDNFMMEAPL QVEFDPSLFE VSATEPAPQP SISTLDTGSP PTSTVPTTSD YPGALGFQLR FLQSSTAKSV TCTYSPDLNK LFCQLAKTCP VQIVVDHPPP PGAVVRALAI YKKLSDVADV VRRCPHHQST SENNEGPAPR GHLVRVEGNQ RSEYMEDGNT LRHSVLVPYE PPQVGSECTT VLYNFMCNSS CMGGMNRRPI LTIITLETQE GQLLGRRSFE VRVCACPGRD RKTEEINLKK QQETTLETKT KPAQGIKRAM KEASLPAPQP GASKKTKSSP AVSDDEIYTL QIRGKEKYEM LKKFNDSLEL SELVPVADAD KYRQKCLTKR VAKRDFGVGP KKRKKLLVKE EKSDSD

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free

Storage

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Description

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Target Background

Function

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.

Gene References into Functions

levels of p53 in rainbow trout tissues and cell lines reported; detection of high p53 levels in gills may reflect need for elevated checkpoint readiness in a tissue that would be expected to be accessible to genotoxic compounds in the aquatic environment PMID:21767662

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Subcellular Location

Cytoplasm. Nucleus.

Protein Families

P53 family

Database Links

UNIGENE: Omy.11581

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