Recombinant Mouse mRNA export factor (Rae1)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Target Background

Product Details

Abbreviation

Rae1

Purity

>85% (SDS-PAGE)

Target Names

Rae1

Uniprot NO.

Q8C570

Alternative Names

Rae1; Mrnp41; mRNA export factor; Rae1 protein homolog; mRNA-associated protein mrnp 41

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

1-368

Target Protein Sequence

MSLFGSTSGF GTGGTSMFGS TTTDNHNPMK DIEVTSSPDD SIGCLSFSPP TLPGNFLIAG SWANDVRCWE VQDSGQTIPK AQQMHTGPVL DVCWSDDGSK VFTASCDKTA KMWDLNSNQA IQIAQHDAPV KTIHWIKAPN YSCVMTGSWD KTLKFWDTRS SNPMMVLQLP ERCYCADVIY PMAVVATAER GLIVYQLENQ PSEFRRIESP LKHQHRCVAI FKDKQNKPTG FALGSIEGRV AIHYINPPNP AKDNFTFKCH RSNGTNTSAP QDIYAVNGIA FHPVHGTLAT VGSDGRFSFW DKDARTKLKT SEQLDQPIAA CCFNHNGNIF AYASSYDWSK GHEFYNPQKK NYIFLRNAAE ELKPRNKK
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Plays a role in mitotic bipolar spindle formation. Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton.

Gene References into Functions

surface NKG2D ligand RAE1epsilon on tumour cells induces CD11b(+) Gr-1(+) myeloid-derived suppressor cell (MDSC) via NKG2D in vitro and in vivo. PMID:28276625
High RAE1 expression is associated with lymphoma. PMID:27477692
An increased expression of the NKG2D ligand MICA in systemic lupus erthematosus (SLE) patients' kidneys and Rae-1 and Mult-1 in various murine SLE models, is reported. PMID:25583577
Results suggest that genomic damage in tumor cells leads to activation of STING-dependent DNA sensor pathways, thereby activating RAE1 and enabling tumor immunosurveillance. PMID:24590060
mouse cytomegalovirus m152/gp40 interaction with RAE1gamma structural analysis reveals a paradigm for MHC/MHC interaction in immune evasion PMID:23169621
VSV M protein blocks mRNA export by disrupting Rae1 function, which can be reverted by induction of Rae1 expression. PMID:15629720
In kidney reperfusion injury, there is a higher rats of mRNA espression PMID:16980040
Hepatic ischemia/reperfusion injury increrases gene expression. PMID:16980045
Blocking RA synthesis by the Raldh inhibitor or blocking retinoic acid signaling by the retinoic acid receptor antagonist abolished upregulation of RAE-1. RA stimulates RAE1 expression and sensitizes early activated HSCs to NK cell killing. PMID:17673545