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Recombinant Mouse Zinc finger protein ZIC 1 (Zic1)

Recombinant Mouse Zinc finger protein ZIC 1 (Zic1)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Zic1

Uniprot NO.

P46684

Alternative Names

Zic1; Zic; Zinc finger protein ZIC 1; Zinc finger protein of the cerebellum 1

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

1-447

Target Protein Sequence

MLLDAGPQYP AIGVTTFGAS RHHSAGDVAE RDVGLGINPF ADGMGAFKLN PSSHELASAG QTAFTSQAPG YAAAAALGHH HHPGHVGSYS SAAFNSTRDF LFRNRGFGDA AAAASAQHSL FAASAGGFGG PHGHTDAAGH LLFSGLHEQA AGHASPNVVN GQMRLGFSGD MYPRPEQYGQ VTSPRSEHYA APQLHGYGPM NVNMAAHHGA GAFFRYMRQP IKQELICKWI EPEQLANPKK SCNKTFSTMH ELVTHVTVEH VGGPEQSNHI CFWEECPREG KPFKAKYKLV NHIRVHTGEK PFPCPFPGCG KVFARSENLK IHKRTHTGEK PFKCEFEGCD RRFANSSDRK KHMHVHTSDK PYLCKMCDKS YTHPSSLRKH MKVHESSSQG SQPSPAASSG YESSTPPTIV SPTTDNPTTS SMSPSSSAVH HTAGHSALSS NFNEWYV
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Involved in the spatial distribution of mossy fiber (MF) neurons within the pontine gray nucleus (PGN). Plays a role in the regulation of MF axon pathway choice. Promotes MF migration towards ipsilaterally-located cerebellar territories. May have a role in shear flow mechanotransduction in osteocytes. Retains nuclear GLI1 and GLI3 in the cytoplasm. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3'.

Gene References into Functions

Geminin and Zic1 could cooperatively activate the expression of several shared targets encoding transcription factors that control neurogenesis, neural plate patterning, and neuronal differentiation. PMID:27881878
Zic1 and Zic2 proteins are essential to control the balance between two defined neuron types in the postnatal forebrain. PMID:28972122
Brn2-Zic1 axis is essential to specify neural fate in retinoic-acid-treated embryonic stem cells. PMID:25991548
Zic1 and Zic2 are required for coordinating mature neuronal gene expression patterns. PMID:25849986
Association with DNA-bound Pax3 strengthens the ability of both Zic1 and Gli2 to transactivate Myf5 in the epaxial somite. PMID:24036067
Zic1 and Zic4 have both Shh-dependent and -independent roles during cerebellar development and multiple developmental disruptions underlie Zic1/4-related Dandy-walker malformation. PMID:21307096
Myf5 activation in newly forming somites is delayed in Zic2 mutant embryos until the time of Zic1 activation, and both Zic2 and Myf5 require noggin for their activation PMID:21211521
Zic1, a neural developmental transcription factor, plays an important role in shear flow mechanotransduction in osteocytes. PMID:20354137
findings suggest that Zic1 controls the expansion of neuronal precursors by inhibiting the progression of neuronal differentiation PMID:11944941
The functions of Zic1 and Zic3 may be essential to increasing neural cell numbers regionally in the medial telencephalon and to proper mediolateral patterning of the telencephalon. PMID:17507568
This study reveal a new role for Zic1 as a cell-autonomous regulator of key aspects of nucleus formation and axon pathway choice in the ventral brain stem. PMID:19303920

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Subcellular Location

Nucleus. Cytoplasm. Note=Localizes in the cytoplasm in presence of MDFIC overexpression.

Protein Families

GLI C2H2-type zinc-finger protein family

Tissue Specificity

Expressed in osteoblasts (at protein level). Expressed in the CNS. A high level expression is seen in the cerebellum, while a low level expression is seen in the olfactory bulb, diencephalon, and brainstem. Expressed in lumbar spine and iliac crest.

Database Links

UNIGENE: Mm.335350

KEGG: mmu:22771

STRING: 10090.ENSMUSP00000034927

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