Recombinant Mouse Wnt inhibitory factor 1 (Wif1)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

Wif1

Purity

>85% (SDS-PAGE)

Target Names

Wif1

Uniprot NO.

Q9WUA1

Alternative Names

Wif1; Wnt inhibitory factor 1; WIF-1

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

29-379

Target Protein Sequence

GQ PPEESLYLWI DAHQARVLIG FEEDILIVSE GKMAPFTHDF RKAQQRMPAI PVNIHSMNFT WQAAGQAEYF YEFLSLRSLD KGIMADPTVN VPLLGTVPHK ASVVQVGFPC LGKQDGVAAF EVNVIVMNSE GNTILRTPQN AIFFKTCQQA ECPGGCRNGG FCNERRVCEC PDGFYGPHCE KALCIPRCMN GGLCVTPGFC ICPPGFYGVN CDKANCSTTC FNGGTCFYPG KCICPPGLEG EQCELSKCPQ PCRNGGKCIG KSKCKCPKGY QGDLCSKPVC EPGCGAHGTC HEPNKCQCRE GWHGRHCNKR YGASLMHAPR PAGAGLERHT PSLKKAEDRR DPPESNYIW
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation.

Gene References into Functions

Wif1 localizes to the enamel knot in which Wif1 regulates apoptosis by mediating and regulating Wnt-beta-catenin signaling. Thus, Wif1 plays an essential role in tooth development. PMID:25893927
WIF1 has a role in breast neoplasms: its inhibition significantly relieves the cancer stem cell-limiting effects of dietary compound isoliquiritigenin PMID:25918249
results demonstrate that Wif1 is not targeted for silencing by DNA methylation in OS. Instead, the reduced expression of Wif1 in OS cells is in context with their stage in differentiation PMID:25571841
EZH2-induced downregulation of WIF1 expression may partially regulate Wnt/beta-catenin-dependent crypt hyperplasia in response to citrobacter rodentium infection PMID:25486432
Dysregulation of this endodermal Shh-Wif1-b-catenin signaling axis contributes to ARM pathogenesis. PMID:24632949
It is anticipated that our findings will contribute to expansion of our understanding of WIF1 biological function on heart development and possible modes of treatment of heart diseases PMID:23921644
WIF1 secretion by the Mullerian duct mesenchyme plays a role in Mullerian duct regression in fetal males PMID:24362065
These data suggest that WIF-1 may take part in the fine-tuning of cartilage and bone turnover, promoting the balance of cartilage versus bone anabolism. PMID:23784913
Wnt inhibitory factor 1 (Wif1) is regulated by androgens and enhances androgen-dependent prostate development PMID:23087175
Osteoblastic Wif1 overexpression disrupts stem cell quiescence, leading to a loss of self-renewal potential. PMID:21652676
wif1 is a modulator of cardiomyocyte differentiation PMID:21179454
a novel regulatory loop of Bmp4-Smad1-Wif1-Wnt/beta-catenin in coordinating BMP and Wnt pathways to control fetal lung development PMID:21270055
WIF-1 protein inhibits rod production, and anti-WIF-1 antibodies increase rod production; in contrast, Wnt4 promotes rod production. PMID:15555925
Dkk-1/Wnt/beta-catenin cascade may mediate the proliferation and migration of hepatocellular carcinoma cells during the metastasis process. PMID:17964517
Wif1 mRNA can be detected as early as the developmental stage E11, and expression persists to adulthood. PMID:18586116
Data provided a full expression pattern for Wif1 in limb development, for which no limb expression had been documented so far. PMID:19185060
Results indicate that WIF-1 plays as a negative regulator of osteoblastic differentiation in mouse mesenchymal C3H10T1/2 cells in vitro. PMID:19254785
targeted deletion of Wif1 accelerated development of radiation-induced osteosarcomas in vivo PMID:19307728