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Recombinant Mouse V-set domain containing T-cell activation inhibitor 1 (Vtcn1)

Recombinant Mouse V-set domain containing T-cell activation inhibitor 1 (Vtcn1)

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MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

Vtcn1

Purity

>85% (SDS-PAGE)

Target Names

Vtcn1

Uniprot NO.

Q7TSP5

Alternative Names

Vtcn1; B7h4; V-set domain containing T-cell activation inhibitor 1; B7 homolog 4; B7-H4; Immune costimulatory protein B7-H4; Protein B7S1; T cell costimulatory molecule B7x

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

25-257

Target Protein Sequence

LIIGFG ISGKHFITVT TFTSAGNIGE DGTLSCTFEP DIKLNGIVIQ WLKEGIKGLV HEFKEGKDDL SQQHEMFRGR TAVFADQVVV GNASLRLKNV QLTDAGTYTC YIRTSKGKGN ANLEYKTGAF SMPEINVDYN ASSESLRCEA PRWFPQPTVA WASQVDQGAN FSEVSNTSFE LNSENVTMKV VSVLYNVTIN NTYSCMIEND IAKATGDIKV TDSEVKRRSQ LQLLNSG
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.

Gene References into Functions

this study shows that B7-H4 knockout hosts mount greater tumor-associated anti-tumor T cell responses and display reduced tumors PMID:28074226
Results highlight an importance of VTCN1 stabilization on cell surfaces for the restoration of altered balance of immune control during T1D. PMID:26773144
B7-H4 expression by nonhematopoietic cells in the tumor microenvironment promotes antitumor immunity. PMID:25527357
that B7x can modulate kidney damage in autoimmune diseases including lupus nephritis and anti-glomerular basement membrane disease PMID:25205493
B7-H4 can inhibit both antitumor T cells and protumor myeloid-derived suppressor cells ( PMID:23686485
The endogenous expression of B7-H4 in donor beta cells from transgenic mice prolongs islet allograft survival, confirming the negative role of B7-H4 in regulating alloreactive T-cell responses. PMID:23192157
Local overexpression of B7x on pancreatic beta cells is sufficient to abolish CD8 T cell-induced diabetes. PMID:22972920
An enhanced T cell response contributes to reduced lethality in a pulmonary infection model with Streptococcus pneumoniae. PMID:22855708
B7-H4 expression may influence the outcome of T-cell tumor cell interactions. Tumor-associated macrophage induced membrane-bound B7-H4 on lung cancer cell represents a novel mechanism by which lung cancer cells evade immune recognition and destruction. PMID:22108530
Overexpression of B7-H4 was shown in tumor infiltrated dendritic cells. PMID:21728826
Tissue-specific expression of B7x protects from CD4 T cell-mediated autoimmunity. PMID:21727190
intact recipient, but not donor, B7-H4 is essential for prolongation of allograft survival by blocking CD28/CTLA4:B7 pathway using CTLA4-Ig. PMID:21143433
studies reveal a novel role for activated hepatic stellate cells in the attenuation of intrahepatic T cell responses by way of expression of the coinhibitory molecule B7-H4. PMID:21064155
May participate in negative regulation of cell-mediated immunity in peripheral tissues PMID:12818165
novel negative costimulator and regulates the threshold of T cell activation PMID:12818166
Genomic DNA of mouse B7-H4 is mapped on chromosome 3 comprised of six exons and five introns spanning 66 kb. PMID:14568939
These results suggest that B7-H4 is one of multiple negative cosignaling molecules that collectively provide a fine-tuning mechanism for T-cell-mediated immune responses. PMID:16914726
T-cell and epithelial cell crosstalk-associated B7-H4 induces T-cell activation and is a potential activator that promotes tubular lesion PMID:17051145
B7-H4 is a negative regulator of the neutrophil response to infection PMID:19109567
Local expression of B7-H4 prolongs islet allograft survival in vivo, suggesting translational potential for beta-cell replacement with reduced immune injury. PMID:19307783
these results suggest a different action of B7-H4 in T cell-mediated inflammatory responses and the possible involvement of soluble B7-H4 in inflammatory immune responses. PMID:19723502

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Subcellular Location

Cell membrane; Lipid-anchor, GPI-anchor.

Protein Families

Immunoglobulin superfamily, BTN/MOG family

Tissue Specificity

Expressed on the surface of professional antigen-presenting cells (at protein level). Widely expressed, including in kidney, liver, lung, pancreas, placenta, prostate, spleen, testis and thymus.

Database Links

UNIGENE: Mm.137467

KEGG: mmu:242122

STRING: 10090.ENSMUSP00000057721

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