Recombinant Mouse Usherin (Ush2A), partial

Mammalian cell

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Target Background

Product Details

Abbreviation

Ush2A

Purity

>85% (SDS-PAGE)

Target Names

Ush2A

Uniprot NO.

Q2QI47

Alternative Names

Ush2A; Gm676; Usherin; Usher syndrome type IIa protein homolog; Usher syndrome type-2A protein homolog

Species

Mus musculus (Mouse)

Source

Baculovirus

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Involved in hearing and vision as member of the USH2 complex. In the inner ear, required for the maintenance of hair bundle ankle formation, which connects growing stereocilia in developing cochlear hair cells. In retina photoreceptors, the USH2 complex is required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport.

Gene References into Functions

Expressed in the cells of the outer nuclear layer of the retina and in cochlea. PMID:12160733
Conservation of usherin is seen at the nucleotide and amino acid level when comparing the mouse and human gene sequences. PMID:12433396
Binding to fibronectin occurs at the LE domain of usherin. PMID:16114888
In mouse inner ears usherin is present at the base of the differentiating stereocilia, which make up the mechanosensitive hair bundles receptive to sound PMID:16301217
Whrn connects to the Usher protein network in the cochlea and retina by direct association with USH2A and VLGR1. PMID:16434480
usherin in photoreceptors is tethered via its C terminus to the plasma membrane and its large extracellular domain projects into the periciliary matrix, where they may interact with the connecting cilium to fulfill important structural or signaling roles PMID:17360538

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Subcellular Location

Cell projection, stereocilium membrane; Single-pass type I membrane protein. Photoreceptor inner segment.; [Isoform 2]: Secreted.

Tissue Specificity

Present in the testis, epididymis, oviduct, spleen, submaxillary gland, and small and large intestines. Not detected in the brain, skin, lung, skeletal muscle, cardiac muscle, liver or kidney. Expressed in smooth muscle of the colon and the epididymis. Al

Database Links

UNIGENE: Mm.331238

KEGG: mmu:22283

STRING: 10090.ENSMUSP00000050454

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