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Recombinant Mouse Ubiquitin-like protein ATG12 (Atg12)

Recombinant Mouse Ubiquitin-like protein ATG12 (Atg12)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

Atg12

Purity

>85% (SDS-PAGE)

Target Names

Atg12

Uniprot NO.

Q9CQY1

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

1-141

Target Protein Sequence

MSEDSEVVLQ LPSAPVGAGG ESLPELSPET ATPEPPSSAA VSPGTEEPPG DTKKKIDILL KAVGDTPIMK TKKWAVERTR TIQGLIDFIK KFLKLVASEQ LFIYVNQSFA PSPDQEVGTL YECFGSDGKL VLHYCKSQAW G
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes.; (Microbial infection) May act as a proviral factor. In association with ATG5, negatively regulates the innate antiviral immune response by impairing the type I IFN production pathway upon vesicular stomatitis virus (VSV) infection.

Gene References into Functions

miR-23a downregulation modulates the inflammatory response by targeting ATG12-mediated autophagy. PMID:29845275
Axonal development is compromised in brains of mir505 knockout mice, in which autophagy signaling and formation of autophagosomes are consistently enhanced. miR505 acts via targeting Atg12. PMID:28820282
miR-30b inhibited autophagy to alleviate hepatic ischemia-reperfusion injury by decreasing the Atg12-Atg5 conjugate. PMID:27182160
Although genetic deletion of either Atg12 or Atg5 renders POMC neurons autophagy-deficient, mice lacking Atg5 in POMC neurons do not exhibit these phenotypes. PMID:25585051
ATG12-ATG3 interacts with Alix to promote basal autophagic flux and late endosome function. PMID:25686249
Atg5-Atg12/Atg16L1 protein complex is required for IFNgamma-mediated host defense against murine norovirus infection. PMID:22520467
Vaccinia virus actively disrupts the cellular autophagy through a novel molecular mechanism that is associated with aberrant LC3 lipidation and a direct conjugation between ATG12 and ATG3. PMID:22024753
Despite forming the Atg12-Atg5-Atg16L2 complex, Atg16L2 is not recruited to phagophores and is mostly present in the cytosol. PMID:22082872
Autophagy participated the process of immune response of anti-MTB. Atg12 were the important molecule which control the formation of autophagy when MTB infected. PMID:19174008
Overexpression of Atg5 or Atg12 resulted in Atg5-Atg12 conjugate formation and suppression of RNA-mediated signaling. PMID:17709747