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Recombinant Mouse Ubiquitin carboxyl-terminal hydrolase 16 (Usp16), partial

Recombinant Mouse Ubiquitin carboxyl-terminal hydrolase 16 (Usp16), partial

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

Usp16

Purity

>85% (SDS-PAGE)

Target Names

Usp16

Uniprot NO.

Q99LG0

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

1-825

Target Protein Sequence

MGKKRTKGRS APDTVASESA EPVCRHLRKG LEQGNLKKAL VNVEWNICQD CKTDNKVKDK PEEEAEDPSV WLCLKCGHQG CGRDSQEQHA LKHYTTPRSE PHYLVLSLDN WSVWCYKCDE EVKYCSSNRL GQVVDYVRKQ AGVRTSKPAE KNNGHIELEN KKLEKESKNE QEREKSENLA KETIPMDSAS QITVKGLSNL GNTCFFNAVM QNLSQTPVLR ELLKEVKMSG TIVKIEPPDL ALTEPLEVNL EPPGPLTLAM SQFLSEMQEN KKRVVTPKEL FSQVCKKATR FKGYQQQDSQ ELLRYLLDGM RAEEHQRVSK GILKAFGNST EKLDEEVKNK VKDYEKKKAI PSFVDRIFGG ELTSTIMCDE CRTVSLVHES FLDLSLPVLD DQSGKKSIND KNVKMTMEEE DKDSEEEKDD SYMKSRSDLP SGTSKHLQKK AKKQAKKQAK NQRRQQKIQE RFLHFNELCA TDYTEDNERE ADTALAGEVE VDTDSTHGSQ EEATQIELSV NQKDLDGQES MIERTPDVQE SPEDLGVKSA NTESDLGIVT PAPECPRDFN GAFLEERTSG ELDIINGLKN LNLNAAVDPD EINIEIPNDS HSAPKVYEVM NEDPETAFCT LANREAFSTD ECSIQHCLYQ FTRNEKLQDA NKLLCEVCSR RQCNGPKANI KGDRRHVYTN AKKQMLVSLA PPVLTLHLKR FQQAGFNLRK VNKHIKFPEI LDLAPFCTLK CKNVAEESTR VLYSLYGVVE HSGTMRSGHY TAYAKERTAS CHLSNLVLHG DIPQDCEMES TKGQWFHISD THVQAVPITK VLNSQAYLLF YERIL
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.

Gene References into Functions

USP16 and TTC3 were dysregulated in all affected human cells and two mouse models of Down syndrome. PMID:27586445
these studies identified Usp16 as one of the histone H2A deubiquitinases, which coordinates with the H2A ubiquitin ligase PRC1 to regulate hematopoiesis, and revealed cell cycle regulation by Usp16 as key for HSC differentiation. PMID:26699484
study identifies Usp16 and H2A deubiquitination as critical regulators of ESC gene expression and differentiation PMID:24784029
results suggest that USP16 has an important role in antagonizing the self-renewal and/or senescence pathways in Down's syndrome and could serve as an attractive target to ameliorate some of the associated pathologies PMID:24025767