Recombinant Mouse Tumor necrosis factor ligand superfamily member 15 (Tnfsf15), partial

1. TL1A blocking ameliorates intestinal fibrosis in the T cell transfer model of chronic colitis PMID:29254800
2. ATF3 protects against LPS-induced acute lung injury by inhibiting TL1A expression. PMID:28177121
3. this study shows that TL1A-/- mice are more susceptible to dextran sodium sulfate colitis PMID:27233964
4. These data demonstrated a direct role for TL1A-DR3 signaling in tissue fibrosis and that modulation of TL1A-DR3 signaling could inhibit gut fibrosis. PMID:24850426
5. TL1A deficiency impacts on the gut microbial composition and the mucosal immune system, especially the intraepithelial TCRgammadelta(+) T-cell subset, and that TL1A is involved in the establishment of adipose tissue. PMID:25404161
6. Our data demonstrate a key role for TL1A in promoting ILC2s at mucosal barriers. PMID:24220298
7. delivers survival signals to plasma cells and promotes pathogenic Ab production in collagen arthritis PMID:24140642
8. TNFSF15 inhibits vasculogenesis by regulating relative levels of membrane-bound and soluble isoforms of VEGF receptor 1. PMID:23918400
9. These results establish a novel link between tumor necrosis factor (TNF)-family cytokine TL1A (TNFSF15) and interleukin 13 (IL-13) responses that results in small intestinal inflammation. PMID:20980995
10. role of TL1A in mucosal T cells and antigen presenting cells function and showed that up-regulation of TL1A expression can promote mucosal inflammation and gut fibrosis. PMID:21264313
11. findings suggest that the transcription factor NF-kappaB plays an important role in the regulation of VEGI expression PMID:15702971
12. neonatal CD4+ CD3- cells up-regulate both CD30L and OX40L after adoptive transfer into an adult recipient PMID:16920944
13. VEGI may have a key role in both the termination of angiogenesis and facilitation of dendritic cell maturation, which is the initial step in immune responses toward inflammatory stimuli. PMID:17785811
14. TL1A may contribute to renal inflammation and injury through DR3-mediated activation of NF-kappaB and caspase-3 PMID:18287561
15. Results reveal that TL1A is an important modulator in the development of chronic mucosal inflammation by enhancing T(H)1 and T(H)17 effector functions. PMID:18598698

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UNIGENE: Mm.208152

KEGG: mmu:326623

STRING: 10090.ENSMUSP00000050144