Recombinant Mouse Transcription factor Maf (Maf)

1. these data demonstrate that c-Maf is an indispensable yet constitutive transcription factor for IL-10 gene expression in LPS-activated B cells PMID:29974486
2. The control of cMaf expression at the translational level by mTOR regulated the expression of inflammatory genes in response to lipopolysaccharide challenge. PMID:29484383
3. results suggest that pathobiont-dependent inflammatory bowel disease is driven by microbiota-reactive T cells that have escaped this c-MAF-dependent mechanism of iTreg-TH17 homeostasis PMID:29414937
4. c-Maf is a critical transcription factor regulating T-cell specialization in mice, essential for generation of both RORgammat(+) Tregs and T follicular regulatory cells, but not for adipose-resident Tregs. c-Maf is induced in Tregs by IL-6 and TGF-beta. PMID:29127150
5. interplay between MATalpha1, c-Myc, and Maf proteins, and their deregulation during chronic cholestasis may facilitate cholangiocarcinoma oncogenesis PMID:26969892
6. HERC4 mediates c-Maf ubiquitination and delays growth of multiple myeloma. PMID:26825710
7. Collectively, these studies show that FGF signaling up-regulates expression of alphaA-crystallin both directly and indirectly via up-regulation of c-Maf. PMID:26719333
8. Tec enhances c-Maf-dependent IL-4 promoter activity. This effect of Tec is counteracted by Ptpn22, which physically interacts with and facilitates tyrosine dephosphorylation of c-Maf thereby attenuating its transcriptional activity. PMID:25993510
9. endogenous small-Maf factors negatively regulate beta-cell function by competing for MafA binding, and thus, the inhibition of small-Maf activity can improve beta-cell function PMID:25763640
10. The melanoma microenvironment contributes to skewing of CD8 T cell differentiation programs, in part by TGFbeta/IL-6-mediated induction of Maf. PMID:26139534
11. Sox5 physically associates with c-Maf via the HMG domain of Sox5 and DNA-binding domain of c-Maf, and Sox5 together with c-Maf directly activates the promoter of RORgammat in CD4(+) T cells. PMID:25073789
12. The p53 transcription factor modulates microglia behavior through microRNA-dependent regulation of c-Maf. PMID:24319262
13. Translocations between IGH and MAF may arise only in the absence of close proximity to the more frequent partners in multiple myeloma. PMID:23460268
14. p53 regulates lens differentiation through modulation of two important transcription factors, c-Maf and Prox1. PMID:22827438
15. inappropriate expression of the fiber cell markers c-maf and Prox1 also occurred, indicating a failure of appropriate lens fiber cell differentiation accompanied by altered lens cell proliferation and cell death. PMID:22491411
16. We found that c-Maf bound to the Il22 promoter and was both necessary and sufficient for the TGF-beta-dependent suppression of IL-22 production in T(H)17 cells. PMID:22001828
17. This study demonistrated that c-Maf is required for the development of dorsal horn laminae III/IV neurons and mechanoreceptive DRG axon projections. PMID:22514301
18. findings show that the transcription factor c-Maf/c-MAF is crucial for mechanosensory function PMID:22345400
19. Data establish a novel regulatory role for Pax6 during lens development, link together the Pax6/c-Maf/crystallin regulatory network, and suggest a novel type of GRN subcircuit that controls a major part of embryonic lens development. PMID:21998302
20. c-Maf is crucial for definitive erythropoiesis in fetal liver, playing an important role in macrophages that constitute erythroblastic islands. PMID:21628412
21. c-Maf is important for the development of memory Th cells, particularly memory Th17 cells and Th1 cells. PMID:21402704
22. Methionine adenosyltransferase II serves as a transcriptional corepressor of Maf oncoprotein PMID:21362551
23. This novel TG mouse model of the human MM t(14;16)(q32;q23) chromosomal translocation should serve to provide new insight into the role of c-MAF in tumorigenesis. PMID:21224354
24. the AhR bound to c-Maf and promoted transactivation of the Il10 and Il21 promoters, which resulted in the generation of Tr1 cells PMID:20676095
25. c-Maf interacts with Ubc9 & PIAS1. c-Maf can be SUMOylated at Lys-33 in Th2 cells. SUMOylation attenuates its transcriptional activity. PMID:20127678
26. c-Maf induces IL-21 production directly in CD4(+) T cells by activating IL-21P and the CNS-2 enhancer and that TGF-beta suppresses c-Maf-induced IL-21 production in CD4(+) T cells. PMID:20042469
27. c-maf promotion of Th2 cytokine production is dependent on CD25 PMID:12271139
28. c-Maf is a potent activator of IL-10 gene expression in monocytes/macrophages that, when overexpressed, selectively inhibits IL-12p40 and p35 gene transcription. PMID:12421951
29. maf has a role in murine cataract and results in selective alteration in DNA binding PMID:12620964
30. c-Maf is required for normal chondrocyte differentiation. PMID:14512017
31. These findings suggest that expression of the c-maf gene may be involved in the embryological development and/or cell differentiation of kidney and liver cells. PMID:15249232
32. tissue-specific expression of alphaA-crystallin is regulated by recruitment of Pax6 and c-Maf PMID:16023139
33. localization of cyclin D1 in developing lens cells of c-maf knockouts; many cyclin D1-positive nuclei were observed in lens epithelial cells and posterior lens cells; results consistent with c-maf role in regulation of cyclin D1 in developing lens cells PMID:16325892
34. Taken together, these data indicate that the CTGF gene is a target of c-Maf and Lc-Maf in cartilage development. PMID:16343439
35. results suggest that c-Maf might cause a type of T-cell lymphoma in both mice and humans and that ARK5, in addition to cyclin D2 and integrin beta(7), might be downstream target genes of c-Maf leading to malignant transformation PMID:16424013
36. Data demonstrate a novel mechanism of Pax6, c-Maf and CREB function, through regulation of chromatin-remodeling enzymes, and suggest a multistage model for the activation of alphaA-crystallin during lens differentiation. PMID:16675956
37. c-maf may be transcriptional regulator of GPx3 expression and modulate the antioxidative pathway in the kidney PMID:16890189
38. c-Maf D90V enhances p300 recruitment in a cell-type dependent manner. PMID:17374726
39. Pax-6 and c-Maf interact with G1 to activate basal expression of the glucagon gene PMID:17901057
40. ICOS-induced c-Maf regulates IL-21 production that in turn regulates the expansion of T(H)-17 and T(FH) cells. PMID:19098919
41. Results suggest that Lc-Maf may affect the process of endochondral ossification by participating in the regulation of Col27a1 expression. PMID:19414009
42. c-Maf is required for the F4/80 expression in macrophages in vivo. PMID:19539733
43. IL-27-driven c-Maf expression transactivates IL-21 production, which acts as an autocrine growth factor for the expansion and/or maintenance of IL-27-induced Tr1 cells PMID:19570826

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UNIGENE: Mm.275549

KEGG: mmu:17132

STRING: 10090.ENSMUSP00000104732