Recombinant Mouse Toll-like receptor 7 (Tlr7), partial

1. Results suggest that toll-like receptor 7 (TLR7) needs to move to the cell periphery to induce robust type I interferon responses in plasmacytoid dendritic cells (pDC). PMID:29150602
2. The results demonstrate that TLR7 activation may trigger innate immunity pathways and induce apoptosis and hypoplasia of neonatal biliary trees in Balb/c mice. The novel findings give an implication of pathogenesis of infantile cholestasis, such as biliary atresia. PMID:27590984
3. TLR7 deletion reduces atherosclerosis in apolipoprotein E-deficient mice. PMID:28405010
4. SZU-101 enhances tumor clearance in vivo, without affecting the TLR7-NF-kappaB pathway activated by the TLR7 agonist in mouse spleen lymphocytes and bone marrow dendritic cells PMID:28000738
5. Up-regulation of TLR7 could eliminate intracellular Mtb through autophagy PMID:28419514
6. conclude that VDD promotes tumor growth in the context of Smad3 disruption, potentially through regulation of TLR7 expression and beta-catenin activation PMID:27456065
7. activation of TLR7 in the mouse bladder induced cystitis with sensory hyperactivity of the bladder PMID:28595240
8. Here, we show that under these circumstances, the Toll-like receptor (TLR)-7/8 ligand imiquimod, but not the TLR3 ligand poly I:C or TLR9 ligand CpG, mediated an effective antitumor response. The rejection of these immune-escaped cancers was mediated by NK cells and CD4(+) T cells, whereas activated CD8(+) T cells were dispensable PMID:28637878
9. TLR7 prevents progression of non-alcoholic fatty liver disease via induced autophagy and released IGF-1 from liver. These findings suggest a new therapeutic strategy for the treatment of NAFLD. PMID:27279075
10. Toll-like receptor 2 (TLR2) controls random motility, while Toll-like receptor 7 (TLR7) regulates chemotaxis of microglial cells via distinct pathways. Furthermore, TLR7 mRNA expression is down-regulated by TLR2 and TLR7 activation. PMID:27554518
11. results provide evidence that G, dG, 8-OHG and 8-OHdG are novel endogenous ligands for TLR7. PMID:26489884
12. Virus infection activates endosomal NOX2 oxidase and restricts TLR7 signaling, and that an endosomal NOX2 inhibitor decreases viral pathogenicity. PMID:28701733
13. TLR7 deficiency attenuates retinal damage in diabetic retinopathy model. PMID:28843858
14. The data demonstrate that an atypical TLR7 signaling pathway contributes to type interferon-beta expression during Y. pestis infection and suggest that the TLR7-driven type I IFN response plays an important role in determining the outcome of plague. PMID:28847850
15. Evaluation of the adjuvant effect of agonists of toll-like receptor 4 and 7/8 in a vaccine against leishmaniasis PMID:28963929
16. these data demonstrate that extracellular-miRNA mimics (miR-34a, -122, -133a, -142, -146a, and -208a) are potent innate immune activators and that the miRNAs most likely induce cytokine production and leukocyte migration through TLR7 signaling PMID:28768728
17. study demonstrates that activation of TLR7 signaling in T cells can inhibit Th17 cell differentiation from naive T cells and IL-17 production in established Th17 cells; further report that downregulation of STAT3 signaling is responsible for TLR7-mediated inhibition of Th17 cells due to induction of suppressor of cytokine signaling 3 and 5 PMID:28652396
18. identification of a novel mechanism by which TLR and type I IFN synergize to promote monocyte/macrophage development from hematopoietic progenitors, a process critical in triggering rapid immune responses during infection PMID:27566824
19. Notch1-Hes-1 signaling controls TLR7-induced autophagic death of macrophage via regulation of P62 in mice with lupus. PMID:27537524
20. Dual TLR2/TLR7 agonist induced the maturation of dendritic cells and primed substantial populations of cytolytic and highly polyfunctional effector CD8(+) T cells in vitro, and safely potentiated the immunogenic properties of a nanoparticulate Ag in vivo, eliciting humoral responses with a balanced TH1/TH2 profile in mice. PMID:28432147
21. determine the effects of a loss of autophagy in dendritic cells (DCs), as well as both B cells and DCs, in a TLR7-mediated model of autoimmunity, similar to systemic lupus erythematosus, where both cell types are critical for disease PMID:28031336
22. findings show that TLR7 activation significantly promoted interphotoreceptor retinoid-binding protein (IRBP)-specific Th17 responses by upregulating RORgammat, IL-17, GM-CSF, and IL-23R expression in experimental autoimmune uveitis mice. PMID:27798152
23. CD72 appears to specifically inhibit B cell response to the endogenous TLR7 ligand Sm/RNP. PMID:27810925
24. TLR8 coupling with SOCS-1 inhibits TLR7-mediated antiviral immunity during WNV infection in mice. PMID:27798161
25. Azithromycin impairs imiquimod-induced dendritic cell activation by decreasing lysosomal acidification and disrupting TLR7 maturation and signaling. PMID:27449383
26. the activation of TLR7 increased CCND3 expression via the downregulation of miR-15b in B cells. PMID:26144250
27. this study demonstrates the critical role of Gfi1 in the regulation of myeloid cells, and prevention of spontaneous lupus autoimmunity by negatively controlling TLR7 signaling PMID:27600904
28. this study shows that beta,beta-dimethylacryloyl alkannin could inhibit psoriasis-activated dendritic cells via the TLR7/8 pathway PMID:27697724
29. Orally administered R848 triggers TLR-7 on CD11c(+) dendritic cells, inducing interleukin-23 (IL-23) expression followed by a burst of IL-22 secretion by innate lymphoid cells, leading to Reg3gamma expression and restoration of colonization resistance against vancomycin-resistant enterococcus. PMID:26912904
30. Aging Impairs the Ability of Conventional Dendritic Cells to Cross-Prime CD8+ T Cells upon Stimulation with a TLR7 Ligand. PMID:26474053
31. Type I Interferons maintain expression of TLR7 in B cells and conventional dendritic cells in different ways; total amount of TLR7 is kept in B cells and TLR7(+) population is retained among conventional dendritic cells. PMID:26621862
32. These data provide direct evidence that B cells require TLR7-dependent priming through an autophagy-dependent mechanism before autoimmunity is induced, thereafter involving many cell types. PMID:26120731
33. describe novel roles for type I IFN and TLR7 signaling in nonhematopoietic cells PMID:26289159
34. Data show that preconditioning with poly(I:C) alters toll-like receptors (TLR) and RIG-I-like receptors (RLRs) responses in opposite directions. PMID:26392465
35. Report chemical conjugation of TLR7 agonist T7 and multi-repeat-epitope of monoclonal gastric cancer 7 antigen exerts antitumor effects. PMID:26185376
36. Our data show that TLR7 excess influences the selection, expansion and diversification of B cells in the germinal center, independent of other genes in the Yaa locus. PMID:25794167
37. an important role of 2'-O-methylation for shaping differential TLR7 or TLR8 activation PMID:25785446
38. Cardiac RNA induces inflammatory responses in cardiomyocytes and immune cells via MyD88-TLR7 signaling. PMID:26363072
39. B-cell intrinsic TLR7 signals promote depletion of the marginal zone in a murine model of Wiskott-Aldrich syndrome. PMID:26256668
40. A mucolipin agonist specifically enhanced TLR7 responses to ssRNAs. PMID:25239130
41. These studies identify that TLR7 stimulation leads to the expansion of IL-10-producing CD19(+) CD1d(hi) B cells, which can suppress allergic lung inflammation via T regulatory cells. PMID:25763771
42. Treatment with Let7c and miR21 restricted dendritic growth of wild-type neurons but not Tlr7(-/-) neurons PMID:25917529
43. activation exacerbated lupus nephritis through dendritic and t-regulatory cells PMID:25341693
44. TLR8 deletion accelerated autoimmunity in lupus-prone mice in response to TLR7 activation. PMID:25424423
45. Inhibition of IDO could enhance the therapeutic efficacy of TLR7 agonists via the increase of T helper type 1 immune response in tumors. PMID:25322876
46. Study demonstrates for the first time that influenza A virus and TLR7 activation enhance the NOX2 oxidase-dependent oxidative burst in macrophages. PMID:24869957
47. This work identifies signalling through TLR7 as a source of pathology in experimental cerebral malaria. PMID:25192715
48. Results suggest that the TLR7 response following Japanese encephalitis virus infection promotes type-1 interferon production and generation of antiviral state which might contribute to protective effect in systemic infection PMID:24909816
49. A single copy of TLR7 in B cells is the minimal requirement for breaking the germinal center-tolerance checkpoint. PMID:25252960
50. TLR7 activation led to myd88-dependent production of pro-inflammatory cytokines in dystrophin-deficient muscle cells. PMID:24368419

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UNIGENE: Mm.23979

KEGG: mmu:170743

STRING: 10090.ENSMUSP00000061853