Recombinant Mouse Toll-like receptor 1 (Tlr1), partial

1. These studies reveal that the costimulatory effects of TLR1-TLR2 signaling in CD8(+) T cells are in part mediated by 4-1BB and are important for mounting an effective antitumor immune response. PMID:27267778
2. B cell TLR1/2, TLR4, TLR7 and TLR9 interact in induction of class switch DNA recombination, modulated by BCR and CD40 in mounting of T-cell independent antibody responses. PMID:25536171
3. TLR9 modulates TLR1 expression in Leishmania major-infected macrophages. PMID:25911242
4. Postradiotherapeutic NO production was dependent on TLR1 gene expression. Although iNOS activity was reduced by inhibiting TLR1 expression with TLR1-siRNA, it was enhanced by TLR1 overexpression. PMID:25632046
5. lipopeptides elicit TLR1/2 and TLR2/6 signaling in the endolysosomes, but not on the cell surface. PMID:24860120
6. We found that CEP specifically synergizes with low-dose TLR2-agonists (but not agonists for other TLRs) to induce production of inflammatory cytokines. Moreover, CEP selectively augments TLR2/TLR1-signaling instead of TLR2/TLR6-signaling PMID:25184331
7. IkappaB-zeta regulates TLR-mediated CSR by inducing AID PMID:25124037
8. aortic angiogenesis is preceded by an immune reaction with overexpression of Toll-like receptors (TLRs) and TLR-inducible genes. PMID:24091496
9. role in TH17 immunity through the activation and recruitment of dendritic cells PMID:23443468
10. Identify TLR1 as a critical innate receptor for protective intestinal T(H)17 immunity. PMID:22778390
11. Graphene significantly stimulates the secretion of cytokines/chemokines via TLR- and NF-kappaB-related signaling pathways PMID:22796167
12. Innate immune detection of Aspergillus fumigatus is mediated by TLR4 and TLR2 together with TLR1 or TLR6 in mice. PMID:22315281
13. a dominant role for TLR1/TLR2 heterodimers in the induction of the early inflammatory response by Borrelia spirochetes in humans PMID:21998742
14. These data suggest that TLR-2, but not TLR-1, plays a role in neonatal hypoxic-ischemic brain injury. PMID:21569241
15. Although Tlr1-, Tlr4- and Tlr6-deficient C57BL/6 mice all show normal susceptibility to autoimmune encephalomyelitis, signs are alleviated in female C57BL/6 mice. PMID:21685327
16. Tlr1 is involved in the recognition of the lipid configuration of native mycobacterial lipoprotein as well as several triacylated lipopeptides. PMID:12077222
17. These data indicate that TLR1 and TLR2 are required for lipoprotein recognition and that defects in the TLR1/2 signaling pathway may account for human hyporesponsiveness to Borrelia burgdorferi OspA vaccination. PMID:12091878
18. Toll-like receptor 2 dimerized with Toll-like receptor 6 or 1 is activated by saturated fatty acid and inhibited by polyunsaturated fatty acid PMID:14966134
19. increased mRNA levels during Salmonella enterica serovar Typhimurium sublethal infection PMID:15731092
20. beta-arrestins are essential negative regulators of innate immune activation via TLR-IL-1R signaling PMID:16378096
21. Contrary to the current model, distinct lipopeptides are recognized by TLR2 in a TLR1- and TLR6-independent manner PMID:16455646
22. Intestinal enteroendocrine cells express TLRs which may be involved in innate immune responses. PMID:17395901
23. JNK1, but not JNK2, activity regulates the expression of the tlr1 gene in the macrophage cell line RAW264.7, as well as in primary CD11b(+) cells. PMID:17664270
24. TLR1 is involved in the regulation of mechanisms that impinge on diabetes development in the NOD mouse. PMID:17785827
25. TLR1 is not involved in the recognition of C. albicans, and TLR1 knock-out (TLR1-/-) mice showed a normal susceptibility to disseminated candidiasis. PMID:18036178
26. Microarray analysis of in vivo Borrelia burgdorferi gene expression in murine skin showed that several genes were altered in TLR1/2-deficient animals compared with wild-type mice. PMID:19754309

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UNIGENE: Mm.273024

KEGG: mmu:21897

STRING: 10090.ENSMUSP00000060793