Recombinant Mouse Tissue factor pathway inhibitor (Tfpi)

1. endogenous TFPI from vascular smooth muscle cells inhibited ferric chloride-induced arterial thrombosis without causing hemostatic effects PMID:28550640
2. TFPI-1 interacts with AMOT, which led to a decrease in the phosphorylation of YAP and further increased the genes expression of the proliferation and migration involved. Our results further confirmed that atherosclerosis was a localized disease. PMID:27875740
3. Results suggest that endothelial cell-anchored TFPI controls lung tumor metastasis, and does so largely through the inhibition of local TF-induced thrombin generation and the regulation of the lung microenvironment in mice. PMID:25945811
4. Data argue against an important role for endogenous TFPI in the antibacterial, inflammatory and procoagulant response during pneumococcal pneumonia. PMID:25832548
5. Results demonstrate that TFPI physiologically modulates thrombin-dependent platelet activation in a manner that is required for successful embryonic development PMID:25954015
6. Tissue factor plays a hitherto unreported role in the generation of macrophage migratory inhibitory factor by vascular smooth muscle cells in atherosclerosis-prone ApoE(-/-) mice. PMID:25677604
7. The increased plasmin generation during the early stages of sepsis could cleave/inactivate TFPI and thus lead to thrombotic complications. PMID:23106863
8. structural features within residues of the 39-loop contribute to the resistance of FIXa to inhibition by plasma inhibitors ZPI and TFPI. PMID:23530052
9. PAK1 negatively regulates the expression of TFPI and additionally contributes to increased TF activity. PMID:23038262
10. Murine models of combined TFPI and factor VIII deficiency were used to examine the impact of TFPI deficiency on bleeding and clotting in hemophilia PMID:22355108
11. Data demonstrate an inhibitory role for TFPI in angiogenesis that is, in part, mediated through peptides within its carboxyl terminus. PMID:22223730
12. TFPI present within platelets functions to limit intravascular thrombus growth, likely through inhibition of the procoagulant activity of blood borne tissue factor. PMID:21233452
13. Data reveal distinct roles for endothelial- and myelomonocytic-derived TFPI. PMID:20516367
14. overexpression of TFPI results in improved hemodynamic performance and reduced pulmonary vascular remodeling in a murine model of hypoxia-induced pulmonary hypertension PMID:19648471
15. inhibits metastasis in an experimental model of lung metastasis of B16 melanoma PMID:12083498
16. the correct balance between TF and TFPI in different organs is required to maintain hemostasis during embryonic development and in adult mice. PMID:15598816
17. both in humans and mice, there are temporal variations in TFPI activity PMID:15604416
18. platelets TFPI is also released in microvesicles or as a soluble protein PMID:17082321
19. partial TFPI deficiency interacts with decreased Thbd function in an organ selective manner to produce fibrin deposition in liver, brain, and placenta vascular beds. PMID:17973652
20. TFPIgamma is a third alternatively spliced form of TFPI that is widely expressed in mouse tissues but not made by human tissues. It contains the first two Kunitz domains and is a secreted, rather than a cell surface-associated, protein. PMID:18503630
21. TFPIalpha cDNA was cloned from pig aortic endothelial cells and found to encode a 279-residue mature protein with 79% overall identity to human TFPIalpha PMID:18611227
22. Pregnancy causes a decrease in APC resistance in mice, which can be explained by the elevation of protein S levels and increased TFPI activity in plasma. PMID:19036061
23. data demonstrate that alternatively spliced isoforms of TFPI are temporally expressed in mouse tissues at the level of protein production PMID:19422457
24. Vascular-directed tissue factor pathway inhibitor overexpression regulates plasma cholesterol and reduces atherosclerotic plaque development. PMID:19713537

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UNIGENE: Mm.124316

KEGG: mmu:21788

STRING: 10090.ENSMUSP00000028487