Recombinant Mouse Thymosin beta-4 (Tmsb4x)

1. Tmsb4X was up-regulated in Crybb2 mutant brain. Additionally, Tmsb4X was co-expressed with Crybb2 at actin-enriched cell ruffles. Over-expression of Tmsb4X in cultured hippocampal neurons inhibited dendritogenesis, which phenocopied Crybb2 knock-down. PMID:29864422
2. expressed prominently in podocytes; modifier of glomerular injury PMID:27575556
3. Our data suggest that Tbeta4 is required for setting correct sarcomere length and for appropriate splicing of titin, not only in the heart but also in skeletal muscle. PMID:27914791
4. Increased Tb4 expression was observed in ethanol treated microglia. Knockdown of Tb4 enhanced ethanol-induced inflammatory mediators tumor necrosis factor-alpha and interleukin-1beta and nitric oxide in BV-2 cells was performed. PMID:27189760
5. Results provide evidence that Tbeta4 regulate the levels of VEGF and MMP-2 via the Wnt/beta-catenin/Lef-1 signaling pathway to influence the growth of blood vessels around hair follicles and to activate cell migration. PMID:27130465
6. we identified the C-terminal four amino-acid variable end of TB4 as the essential and responsible domain for the molecule's full benefits in the hypoxic heart. PMID:26255251
7. From the results, Tbeta4 increased the viability and promoted the differentiation and mineralization of MC3T3-E1 cells on Ti discs. PMID:27433712
8. this study demonstrated, for the first time, that Tbeta4 was down-regulated in ROS-stimulated PDLCs as well as Tbeta4 activation exhibited anti-inflammatory effects and anti-osteoclastogenesis in vitro. PMID:26789270
9. this study demonstrates, for the first time, that Tbeta4 is expressed in developing periodontal tissue and that its expression is associated with osteoblastic/cementoblastic differentiation. PMID:26361868
10. Tbeta4 appears to regulate P38/ERK/AKT signaling via its effect on VEGF expression, with a resultant effect on the speed of hair growth, the pattern of HFs and the number of hair shafts PMID:26083021
11. This study provides putative information concerning the signaling pathway through which Tb4 induces RUNX2 expression, which may help to understand the regulation of tooth development and tooth regeneration. PMID:25739055
12. Tbeta4 substantially inhibited bleomycin-induced IL-17 over-expression in the lung tissue: a decreased amount of IL17-producing cells and inhibited IL-17 expression in lung with Tbeta4 treatment correlate with its anti-inflammatory and anti-fibrotic effects. PMID:24613476
13. The results suggest that Tbeta4 plays multiple functional roles in odontogenic epithelial cells in the early stages of tooth germ development by regulating the expression of odontogenesis-related genes. PMID:23052839
14. Analysis at 21 days post-fracture show that the fractional volume of new mineralized tissue and new highly mineralized tissue are greater in calluses from Tbeta4-treated mice compared to controls. PMID:25042765
15. These data suggest that Tbeta4 suppresses the TLR proinflammatory pathway by up-regulating miR-146a. PMID:24828499
16. Demonstrate that Tbeta4 is dispensable for embryonic viability and vascular development. PMID:23371905
17. Thymosin beta4 may play a role in aging-related hearing loss. PMID:15813012
18. These data show that thymosinbeta4 and beta-actin are over-expressed during nurse cell formation upon T. spiralis infection and may be involved in nurse cell formation along with other actin-binding proteins. PMID:22305657
19. Thymosin beta4 is a novel endothelial secreted trophic factor that functions synergistically with TGFbeta to regulate mural cell development and vascular wall stability. PMID:22723298
20. The results suggest that Tb4 may be involved in oral epithelial cell proliferation at the initial stage of tooth development and regulates the expression and secretion of proteins during odontoblast differentiation. PMID:22344518
21. Tbeta4 may influence the remodeling of collicular neuronal processes, possibly in the context of a re-alignment of the sensory and motor maps in the deep superior colliculus after monocular deprivation. PMID:21626305
22. Tbeta4 is dispensable for embryonic viability, heart development, coronary vessel development, and adult myocardial function. PMID:22158707
23. results suggest that in Trichinella spiralis infection, the expression of VEGF and thymosin beta4 induce angiogenesis and the expression of thymosin beta4 remained elevated to potentially regulate nurse cell formation and maintenance PMID:21531510
24. In a mouse model of multiple myeloma thymosin beta4 overexpression leads to significantly decreased proliferative and migratory capacity and increased sensitivity to apoptosis induction. PMID:19833631
25. Hand1-mediated activation of Tbeta4 is essential for yolk sac vasculogenesis and embryonic survival, and administration of synthetic TB4 partially rescues yolk sac capillary plexus formation in Hand1-null embryos. PMID:20975697
26. Downregulation of thymosin beta4 in neural progenitor grafts promotes spinal cord regeneration. PMID:19861493
27. Data show that in mouse tissues, thymosin beta4 is associated with microglia and macrophages. PMID:19631707
28. Up-regulation of Tb4 gene expression may be responsible for the disintegration of the musculature during the development of adenomyosis PMID:14758721
29. thymosin beta4 promotes cardiomyocyte migration, survival and repair PMID:15565145
30. Promoter and silencer were found in the first exon of the thymosin beta 4 gene. PMID:16010974
31. thymosin beta4 (Tbeta4) as essential for all aspects of coronary vessel development in mice PMID:17108969
32. mediator of progenitor cell -mediated cardioprotection in myocardial reperfusion injury PMID:18427126

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UNIGENE: Mm.142729

KEGG: mmu:19241

STRING: 10090.ENSMUSP00000107795